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Glossary Immunodeficiency

condition where the immune system can't effectively fight infections

Immunodeficiency, also known as immune deficiency, refers to a state where the immune system's ability to fight infectious diseases and cancer is compromised or entirely absent. This can be due to genetic conditions (primary immunodeficiency) or external factors such as infections, malnutrition, or medical treatments like chemotherapy (secondary immunodeficiency).

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Research

5 / 1000+ results

Immune Deficiency-Related Enteropathy-Lymphocytopenia-Alopecia Syndrome Results from Tetratricopeptide Repeat Domain 7A Deficiency

research Immune deficiency–related enteropathy-lymphocytopenia-alopecia syndrome results from tetratricopeptide repeat domain 7A deficiency

64 citations , August 2014 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

This study found that biallelic mutations in the TTC7A gene affect lymphocyte and gut epithelial cell function, thereby contributing to the development of inflammatory bowel disease in patients.

research Deficient anterior pituitary with common variable immune deficiency (DAVID syndrome): a new case and literature reports

1 citations , May 2023 in “Journal of neuroendocrinology”

This review of DAVID syndrome cases found that ACTH deficiency often preceded by sinus infections or alopecia is linked to specific NFKB2 gene mutations, highlighting the importance of early diagnosis to prevent complications.

Iron Deficiency in Immune-Mediated Inflammatory Skin Diseases: A Missing Link Between Systemic Inflammation, Immunometabolism, and Disease Burden

research Iron Deficiency in Immune-Mediated Inflammatory Skin Diseases: A Missing Link Between Systemic Inflammation, Immunometabolism, and Disease Burden

March 2026 in “Cells”

This review highlights that iron deficiency is a significant yet often overlooked contributor to the development of immune-mediated inflammatory skin diseases, suggesting that iron dysregulation may drive inflammation and metabolic imbalances in conditions like psoriasis and atopic dermatitis.

research ZINC AND HUMAN HEALTH: IMPLICATIONS OF ZINC DEFICIENCY IN IMMUNE, GASTROINTESTINAL, DERMATOLOGICAL, AND METABOLIC DISORDERS

January 2026 in “International Journal of Innovative Technologies in Social Science”

This narrative review explores existing evidence on zinc's impact in certain immune-related, gastrointestinal, dermatological, and metabolic disorders, considering clinical and observational studies to assess zinc supplementation's clinical relevance.

research Immunodeficiency Disorders

21 citations , May 2019 in “Pediatrics in review”

This review examines primary and secondary immunodeficiencies, focusing on how healthcare providers can recognize and manage these conditions in children; it reports no new clinical results.

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Community Join

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community Vitamin E and K deficiency (F,25)

in Research/Science 3 upvotes 4 months ago

Vitamin E and K deficiencies due to exocrine pancreatic insufficiency may affect hair growth. A scalp biopsy is recommended to check for autoimmune-related hair loss.

community Iron Overload and Vitamin D Deficiency - Male Hair Loss

18 upvotes 4 years ago

The conversation discusses hair loss treatments, specifically minoxidil, vitamin D supplements, and the potential impact of iron overload. The user experienced hair regrowth with high-dose vitamin D but faced hair thinning again after reducing the dosage, and is now exploring the role of iron overload in hair loss.

community Has anyone used zinc as a treatment?

24 upvotes 1 year ago

Zinc is not effective for hair loss unless there's a deficiency. Finasteride and minoxidil are recommended treatments.

community Please take a vitamin & hormone test

255 upvotes 1 year ago

Checking vitamin and hormone levels is important for addressing hair loss, as deficiencies in vitamin D, zinc, and iron can affect hair growth. Treatments like finasteride, minoxidil, and vitamin supplements are used, but addressing deficiencies is crucial for effectiveness.

community Dutasteride thins eyebrows and facial hair but doesn't stop scalp loss.

in Finasteride/Dutasteride 37 upvotes 1 year ago

Dutasteride may not effectively stop scalp hair loss and can cause thinning of facial and body hair, including eyebrows. Users suggest considering other causes like autoimmune conditions or vitamin deficiencies and exploring treatments like finasteride or minoxidil.

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Learn

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learn Vitamin D

vitamin you should probably be taking for general health might also help your hair a little

learn Stem Cell Factor

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn procapil

Tried everything and still getting bald patches? Procapil may help calm the immune response Procapil is a cosmetic ingredient complex; laboratory studies of its individual ingredients report anti-inflammatory effects, but no published clinical trial has tested it in alopecia areata or any other immune-related hair loss. Spreading bald patches should be assessed by a dermatologist.

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