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Glossary Hydroxyl Radicals

highly reactive molecules damaging cells and DNA

Hydroxyl radicals (OH radicals) are highly reactive molecules that contain one oxygen and one hydrogen atom. They are often formed during the breakdown of water molecules by ultraviolet light or through certain chemical reactions. In biological systems, hydroxyl radicals can cause significant damage to cells, proteins, and DNA, contributing to aging and various diseases, including those affecting hair health and potentially leading to conditions like alopecia.

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Preferential Recognition of Hydroxyl Radical-Modified Superoxide Dismutase by Circulating Autoantibodies in Patients with Alopecia Areata

research Preferential Recognition of Hydroxyl Radical-Modified Superoxide Dismutase by Circulating Autoantibodies in Patients with Alopecia Areata

12 citations , January 2014 in “Annals of Dermatology”

This study found an association between hydroxyl radical-modified SOD and alopecia areata, suggesting these modifications may lead to antibody induction in the condition.

research Hydroxyl radical mediates cisplatin-induced apoptosis in human hair follicle dermal papilla cells and keratinocytes through Bcl-2-dependent mechanism

52 citations , May 2011 in “APOPTOSIS”

In this study, cisplatin was found to induce cell death in human hair follicle cells through hydroxyl radical generation and Bcl-2 down-regulation, suggesting potential strategies for preventing chemotherapy-induced alopecia.

research Mechanism of Cuticle Hole Development in Human Hair Due to UV-Radiation Exposure

8 citations , March 2018 in “Cosmetics”

In this study, researchers found that UV radiation causes hydroxy radicals to form cuticle holes specifically between the cuticle layers in wet hair, unlike random holes caused by Fenton's reaction.

research Ultrasonic-assisted extraction and in-vitro antioxidant activity of polysaccharide from Hibiscus leaf

59 citations , August 2014 in “International Journal of Biological Macromolecules”

In this study, the researchers optimized the extraction conditions for crude polysaccharide from Hibiscus rosa-sinensis leaves, achieving a yield of 9.66% and demonstrated strong antioxidant activities in vitro.

research Premature Graying as a Consequence of Compromised Antioxidant Activity in Hair Bulb Melanocytes and Their Precursors

46 citations , April 2014 in “PLOS ONE”

This study found that compromised antioxidant activity in gray hair follicles affects both mature melanocytes and their immature precursors, linked to down-regulation of melanogenesis-related genes.

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