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Glossary Hormonal Changes

variations in hormone levels affecting bodily functions and processes

Hormonal changes, also known as hormonal fluctuations, refer to variations in the levels of hormones in the body. These changes can occur naturally due to life stages such as puberty, pregnancy, and menopause, or due to medical conditions and treatments. Hormonal changes can significantly impact various bodily functions, including metabolism, mood, and hair growth, potentially leading to conditions like alopecia.

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Research

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research Changes in the level of sex hormones with aging and their influence on the voice

January 2023 in “Zdravstvena zaštita”

This review evaluates current research on how hormonal changes due to aging impact voice quality, concluding the vocal cords are sensitive to hormonal fluctuations throughout life but reports no new clinical results.

research 8483 Changes in kidney hemodynamics during gender-affirming hormone therapy in transgender individuals - findings from the KNIGHT pilot study

October 2024 in “Journal of the Endocrine Society”

This study found that feminizing hormone therapy increased GFR in transgender individuals assigned male at birth, suggesting an effect of sex hormones on kidney hemodynamics, while masculinizing therapy showed a slight, nonsignificant decrease in GFR.

research Managing Menopausal Skin Changes: A Narrative Review of Skin Quality Changes, Their Aesthetic Impact, and the Actual Role of Hormone Replacement Therapy in Improvement

4 citations , August 2025 in “Journal of Cosmetic Dermatology”

This study found that while hormone replacement therapy can improve skin aging in menopausal women, inconsistent findings and a lack of robust clinical trials mean it isn't recommended purely for skin benefits.

research Dermal Changes in Osteoporosis Following Prolonged Treatment with Human Growth Hormone

9 citations , October 1976 in “Journal of Cutaneous Pathology”

This study observed that human growth hormone treatment in osteoporosis patients appeared to improve skin thickness and restore dermal structures towards normal without stimulating hair, sebum, or melanin.

research Postmenopausal hormone replacement therapy and changes in skin connective tissue

January 2011 in “Zhongguo shiyong fuke yu chanke zazhi”

This study concludes that hormone therapy can significantly improve skin hydration, elasticity, thickness, and reduce wrinkles by modulating various skin cells through estrogen receptors.

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Community Join

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community Minoxidil: How It Changes the Scalp Hormone Environment

78 upvotes 7 months ago

Minoxidil increases blood supply to the scalp, strengthening dormant follicles and extending the growth phase, but may increase scalp activity that can be countered with DHT blockers. Women experiencing side effects from finasteride or dutasteride for hair loss might consider alternatives like estrogen, especially if on birth control.

community Anyone tried winlevi for hair loss? I am curious about it as someone who doesn’t want to change my hormones systemically.

2 upvotes 6 months ago

Winlevi is being considered for hair loss by someone who wants to avoid systemic hormonal changes. Minoxidil, finasteride, and RU58841 are also mentioned as treatments.

community Topical finasteride has affected my hormones

25 upvotes 2 years ago

A 21-year-old experienced hormone changes after using self-made topical finasteride for hair loss, including a 20% decrease in DHT, a 47% increase in testosterone, and a 39% increase in estradiol. The user previously used minoxidil and microneedling but is now seeking ways to balance hormones, possibly through supplements or dosage adjustments.

community Hormone tests to decide on oral fin

4 upvotes 1 year ago

The conversation discusses starting low-dose oral finasteride for hair loss, considering hormone levels and potential side effects like gynecomastia. Suggestions include using DIM for estradiol, vitamin B6 for prolactin, and lifestyle changes to optimize hormone profiles before starting treatment.

community Dutasteride Hormone Roller Coaster - Testosterone down, then up, then level, then estrogen up

4 upvotes 3 years ago

Dutasteride effectively stops hair loss but can cause side effects like sexual dysfunction, muscle mass changes, and testicle shrinkage. Adjusting the dosage may help manage these side effects, but long-term health effects remain a concern.

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Learn

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learn Melatonin

Hormone that regulates sleep, sold as a supplement

learn Estradiol

Estrogen hormone, prescribed in tablet, patch and gel forms

Why is Estradiol used to treat hair loss in women and transgender people undergoing hormone therapy? Estradiol is used within supervised hormone therapy and may slow hormone-related hair loss in some women and trans women, but the evidence is limited and it carries serious whole-body risks.
Is applying Estradiol directly to the scalp effective for hormone-related hair thinning? There are no good-quality trials showing that estradiol applied to the scalp treats hormone-related thinning. Skin-applied estradiol can still enter the bloodstream and pass to others through contact.

learn Finasteride

Popular 5-alpha reductase inhibitor that lowers DHT, taken as a pill or used topically

learn Hair Transplant

Surgery that moves hair follicles from the back of the scalp to thinning areas

learn Alfatradiol

Weak form of estrogen applied to the scalp

learn Centella

Hormone-related scalp sensitivity: is there evidence for a centella mask? Centella asiatica has anti-inflammatory and wound-healing effects in animal and cell studies, but no published research has tested a centella scalp mask on the human scalp, in hormonal contexts or otherwise, and no community reports were found of one being used this way.

learn procapil

Does Procapil block DHT without affecting hormones? What the evidence shows Procapil's supplier describes it as inhibiting 5-alpha reductase at the scalp without changing hormone levels, but the published support is cell and animal work plus one small human study of a caffeine-plus-Procapil formula. It is a cosmetic ingredient, not an approved hair-loss treatment, and no trial has compared it with finasteride or minoxidil.

learn Clascoterone

Can I use clascoterone if I'm undergoing gender-affirming hormone therapy? No published clinical trial has tested clascoterone in people on gender-affirming hormone therapy, so its safety in that group is unknown. The FDA label reports low systemic exposure and no described effect on blood testosterone, but it also records HPA-axis suppression and raised potassium in a small minority of subjects.

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