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GlossaryHomeobox Genes

regulatory genes controlling body plan and organ development

Homeobox genes, often referred to as Hox genes, are a group of regulatory genes that play a crucial role in determining the body plan and the formation of tissues and organs during early embryonic development. They contain a specific DNA sequence called the homeobox, which encodes a protein domain (the homeodomain) that can bind to DNA and regulate the expression of other genes. This precise regulation ensures that body structures form in the correct locations.

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research Altered Skin Wound Healing in Homeobox Gene Msx-2 Knockout Mice

June 2008 in “Wound Repair and Regeneration”

Msx-2 gene removal speeds up skin wound healing in mice.

research Epidermal Dysplasia and Abnormal Hair Follicles in Transgenic Mice Overexpressing Homeobox Gene MSX-2

49 citations , August 1999 in “Journal of Investigative Dermatology”

research Gene Expression Patterns During Palatal Shelf Fusion

August 2004 in “Journal of the American College of Surgeons”

Several genes, including Hox-7A, Stra6, and Lim-1, are involved in normal palate formation.

research Structure and Expression of the Ovine Hoxc-13 Gene

12 citations , December 2003 in “Gene”

The ovine Hoxc-13 gene is crucial for hair formation and may have other skin functions.

research Faculty Opinions Recommendation of Modulation of Phospholipid Signaling by GLABRA2 in Root-Hair Pattern Formation

September 2003 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

GLABRA2 gene controls root-hair growth by regulating phospholipid signaling.

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