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GlossaryHedgehog Pathway Inhibitors

drugs that block cell growth signals to treat cancer

Hedgehog Pathway Inhibitors are drugs that block the Hedgehog signaling pathway, which is crucial for cell growth and differentiation during embryonic development. In adults, abnormal activation of this pathway can lead to cancers such as basal cell carcinoma. By inhibiting this pathway, these drugs can help treat certain types of cancer by preventing the uncontrolled growth of cancer cells.

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research From Basal Cell Carcinoma Morphogenesis to Alopecia Induced by Hedgehog Inhibitors: Connecting the Dots

17 citations , June 2017 in “British Journal of Dermatology”

The article concludes that hair loss is a common side effect of drugs treating skin cancer by blocking the hedgehog pathway, but treatment should continue, and more selective drugs might prevent this side effect.

research Abstract CN06-04: The Hedgehog Signaling Pathway in Cancer

November 2011 in “Molecular Cancer Therapeutics”

The Hedgehog signaling pathway is linked to cancer development, and targeting it with inhibitors shows promise but faces challenges like resistance.

research Aberrant Activation of the Hedgehog Signaling Pathway in Malignant Hematological Neoplasms

68 citations , November 2011 in “The American journal of pathology”

Abnormal Hedgehog signaling in blood cancers may help tumors grow and resist chemotherapy, suggesting potential for targeted treatments.

research Basal Cell Carcinoma, Hedgehog Signaling, and Targeted Therapeutics: The Long and Winding Road

15 citations , October 2014 in “Journal of Investigative Dermatology”

New treatments targeting the Hedgehog pathway can help treat advanced skin cancer but may have side effects and their effectiveness in early stages is unknown.

research Oncogenes and Morphogens: Intricacies of Targeted Therapy in Cutaneous Basal Cell Carcinoma

December 2017 in “British Journal of Dermatology”

Targeted therapy for skin cancer is complex due to the role of the hedgehog pathway in both cancer and hair growth.

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community Topical finasteride now the safest possible path?

in Finasteride/Dutasteride 84 upvotes 1 year ago

Topical finasteride is considered a safer option for hair regrowth with fewer systemic side effects compared to oral finasteride. Some users report similar efficacy and side effects between topical and oral treatments, while others prefer topical due to reduced systemic exposure.

community Massive hair gains! Hope! May this post be a light to you in dark phases when all other lights go out

in Progress Pictures 193 upvotes 1 year ago

A 27-year-old man saw significant hair regrowth after starting a regimen in January that included topical minoxidil with finasteride, vitamins D and B12, fish oil, zinc with magnesium, quitting smoking, and intermittent fasting. People commented on the effectiveness of minoxidil in Southern populations and asked about the details and timeline of his treatment.

community Found a Pharmacy that will mix me 0.1 % Alfatradiol (Pantostin)

in Treatment 6 upvotes 1 year ago

The user is currently using 0.025% Pantostin but plans to switch to 0.1% Alfatradiol. They will also use high-dose Kx826, high-dose Minoxidil, and aggressive microneedling for hair regrowth.

community Alcohol-free minoxidil available in Europe

in Minoxidil 5 upvotes 1 week ago

Alcohol-free minoxidil options in Europe, particularly from a German pharmacy, are recommended for those with seborrheic dermatitis. Users suggest alternatives like Alopexy and Doppelherz foam, and emphasize avoiding propylene glycol and alcohol to reduce irritation.

community Topical Dutasteride Seems to Work

in Research/Science 22 upvotes 4 weeks ago

Topical dutasteride, particularly at 0.05%, shows greater hair density improvement than oral finasteride over 24 weeks, though hair thickness gains are similar. Some users report side effects with topical treatments, but others find them effective for maintaining hair without significant systemic absorption.

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