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    GlossaryHedgehog Pathway Inhibitors

    drugs that block cell growth signals to treat cancer

    Hedgehog Pathway Inhibitors are drugs that block the Hedgehog signaling pathway, which is crucial for cell growth and differentiation during embryonic development. In adults, abnormal activation of this pathway can lead to cancers such as basal cell carcinoma. By inhibiting this pathway, these drugs can help treat certain types of cancer by preventing the uncontrolled growth of cancer cells.

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      community Topical finasteride now the safest possible path?

      in Finasteride/Dutasteride  82 upvotes 5 months ago
      Topical finasteride is considered a safer option for hair regrowth with fewer systemic side effects compared to oral finasteride. Some users report similar efficacy and side effects between topical and oral treatments, while others prefer topical due to reduced systemic exposure.

      community Massive hair gains! Hope! May this post be a light to you in dark phases when all other lights go out

      in Progress Pictures  193 upvotes 7 months ago
      A 27-year-old man saw significant hair regrowth after starting a regimen in January that included topical minoxidil with finasteride, vitamins D and B12, fish oil, zinc with magnesium, quitting smoking, and intermittent fasting. People commented on the effectiveness of minoxidil in Southern populations and asked about the details and timeline of his treatment.

      community Finasteride only: Before vs 11 months

      in Progress Pictures  437 upvotes 4 months ago
      A user shared progress pictures showing hair improvement after 11 months of using finasteride. The user experienced minimal shedding and plans to continue the treatment long-term.

      community bye fellas, it’s time to quit this sub

      in Progress Pictures  810 upvotes 8 months ago
      A user successfully improved their hairline after 15 months using topical minoxidil and dutasteride. Some commenters question the necessity of treatment given the user's original hair condition, while others support early intervention.

      community Topical Finasteride strength discussion

      in Research/Science  66 upvotes 10 months ago
      The conversation discusses the effectiveness of different concentrations and dosages of topical finasteride on scalp and serum DHT levels, comparing it to oral finasteride and noting the side effects seem to be fewer at lower dosages. Participants shared experiences and referenced a chart indicating similar scalp DHT reduction with 0.025% topical finasteride as with 1mg oral finasteride, but with fewer side effects.

      community Why nobody uses 0.25% (2.5mg/ml)?

      in Treatment  66 upvotes 11 months ago
      The conversation is about the effectiveness of 0.25% topical finasteride compared to other concentrations and forms. Users discuss its potential for better scalp DHT reduction and fewer side effects, with some preferring topical over oral treatments.

      community How insane is this oral min shed?

      in Progress Pictures  111 upvotes 1 year ago
      A user started taking 0.625mg oral minoxidil daily for hair loss, increased the dose to 1.25mg, and experienced a significant shed, losing 70% of scalp density. They cannot tolerate finasteride due to side effects but are hopeful for hair regrowth despite the shedding.

      community Iron Overload and Vitamin D Deficiency - Male Hair Loss

      in Treatment  19 upvotes 2 years ago
      The conversation discusses hair loss treatments, specifically minoxidil, vitamin D supplements, and the potential impact of iron overload. The user experienced hair regrowth with high-dose vitamin D but faced hair thinning again after reducing the dosage, and is now exploring the role of iron overload in hair loss.

      community Almost 90 days. The hair gods taketh and now giveth.

      in Progress Pictures  721 upvotes 1 year ago
      User "mynameisbogus" shares hair regrowth progress after 90 days using Dutasteride, oral and topical Minoxidil, RU58841, dermarolling, and Keto shampoo. Others in the conversation praise the impressive results and discuss their own experiences with hair loss treatments.