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Cedrol Mitigates Hepatic Lipid Accumulation and Adipocyte Hypertrophy Induced by Corticosteroids Through the Inhibition of Glucocorticoid Receptor Activity

research Cedrol mitigates hepatic lipid accumulation and adipocyte hypertrophy induced by corticosteroids through the inhibition of glucocorticoid receptor activity

December 2025 in “Scientific Reports”

In this study, cedrol was found to reduce lipid accumulation in the liver and adipose tissues of dexamethasone-treated mice by antagonizing glucocorticoid receptors, suggesting its potential utility in treating dexamethasone-induced lipid metabolism disorders.

Effective Amelioration of Hepatic Inflammation and Insulin Response in High-Fat Diet-Fed Rats via Regulating AKT/mTOR Signaling: Role of Lepidium Sativum Seed Extracts

research Effective amelioration of hepatic inflammation and insulin response in high fat diet-fed rats via regulating AKT/mTOR signaling: Role of Lepidium sativum seed extracts

14 citations , October 2020 in “Journal of ethnopharmacology”

This study found that both ethanol and aqueous extracts of Lepidium sativum seeds improved insulin signaling and reduced obesity-related metabolic changes in high-fat diet-fed rats, suggesting potential as a dietary supplement.

research Metabolic dysfunction in female mice with disruption of 5α-reductase 1

11 citations , January 2017 in “Journal of Endocrinology/Journal of endocrinology”

This study observed that female mice with disrupted 5α-reductase 1 showed increased insulin resistance and hepatic steatosis, suggesting altered glucocorticoid metabolism contributes to metabolic disorders.

research Elevated fasting insulin is associated with cardiovascular and metabolic risk in women with polycystic ovary syndrome

17 citations , May 2019 in “Diabetes and Metabolic Syndrome: Clinical Research and Reviews”

This study found that fasting insulin levels are associated with increased cardiovascular and metabolic risk factors in women with polycystic ovary syndrome.

research Rodent models in placental research. Implications for fetal origins of adult disease

7 citations , January 2022 in “Animal Reproduction”

This review examines rodent models to explore how maternal conditions like undernutrition, obesity, hypoxia, and androgen exposure affect fetal programming and metabolic outcomes in offspring, but presents no new clinical findings.

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community Having androgen receptor density and sensitivity at wrong f*ing place

in Satire 7 upvotes 1 year ago

The conversation discusses hair loss treatments, focusing on the use of topical minoxidil, microneedling, finasteride, and dutasteride, while debating the role of testosterone and DHT in hair loss. It also touches on the potential liver health impacts of these treatments and the genetic sensitivity of hair follicles to androgens.

community A warning to those using or thinking about using Dutasteride – Follow-up

18 upvotes 5 years ago

The post and conversation are about the long-term side effects of using Dutasteride and Finasteride for hair loss, including issues like raised liver enzymes, high cholesterol, and loss of libido. The user advises regular blood work and careful monitoring for those using these treatments.

community Update: 9 months of oral Dutasteride & topical Minoxidil has done more than I ever expected

831 upvotes 4 months ago

Oral Dutasteride and topical Minoxidil significantly improved hair regrowth over nine months. Other users shared mixed results and side effects with treatments like oral Minoxidil and Finasteride.

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