This study found that high wool-producing Wan Strain Angora rabbits had higher hairfollicledensity and identified potential regulatory long noncoding RNAs that may influence this trait.
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November 2019 in “The FASEB Journal”
In this study, a missense mutation in the MAP2 gene was found to be associated with reduced hairfollicledensity, leading to the hairless phenotype in pigs.
This study explored the spatial variation of THFD in cashmere goats and identified four genes associated with it, offering insights that could aid in the development of THFD genes for these animals.
May 2026 in “Malaysian Journal of Medicine and Health Sciences”
This study found that in a testosterone-induced androgenetic alopecia mouse model, the combination of PRP-derived small extracellular vesicles and 5% minoxidil significantly improved hairfollicledensity and the anagen-to-telogen ratio compared to minoxidil alone, suggesting a synergistic effect that enhances hair growth.
The conversation discusses concerns about getting a hair transplant with the potential release of a new treatment, PP405, which may regrow dormant hairfollicles. The user is currently using Minoxidil, Derma, and Keto but is waiting to start finasteride or dutasteride.
The conversation discusses hair loss treatments, focusing on the use of topical minoxidil, microneedling, finasteride, and dutasteride, while debating the role of testosterone and DHT in hair loss. It also touches on the potential liver health impacts of these treatments and the genetic sensitivity of hairfollicles to androgens.
Redensyl is a plant-based treatment that may support hair regrowth by reactivating dormant follicles and improving hairdensity, especially in early-stage thinning. It is not a miracle cure and results vary; it is less proven than Minoxidil or Finasteride and may cause scalp irritation.
PP405 shows promise in reactivating dormant hairfollicles, with 31% of users experiencing a 20% increase in hairdensity in a short period. It may work faster than minoxidil and without side effects, but its long-term effectiveness is still uncertain.
Hairfollicle stem cells remain in bald individuals, but progenitor cells do not, raising questions about hair regrowth claims by Pelage. PP405 is discussed as a potential treatment, with skepticism about its effectiveness compared to existing treatments like Minoxidil and Finasteride.
Does hair strand thickness decrease in men with androgenic alopecia? Can finasteride help restore it?Androgenic alopecia thins hair strands by miniaturizing follicles. The pivotal finasteride trials (1,553 men, 1 mg/day, two years) report increased hair counts and improved assessed appearance, but they measured density, not the diameter of individual strands, so the effect on thickness itself is not established.
How does cetirizine reduce inflammation linked to hair loss?Cetirizine is proposed to lower prostaglandin D2 and raise prostaglandin E2 around hair follicles; three small trials of a compounded 1% topical report modest increases in hair density and shaft thickness, with minoxidil doing better head-to-head. Topical cetirizine is off-label and unapproved for hair loss, and the evidence is too thin to call it effective or safe.
How long does it usually take to see thicker hair with stemoxydine products?The manufacturer's three-month studies, run in men only and published as a conference abstract, measured a density increase at about 12 weeks, so roughly three months is the earliest point supported by evidence. Nothing beyond three months has been tested in a controlled trial, and the change measured is extra visible hairs rather than regrowth of lost follicles.
Does metformin help control DHT levels that trigger androgenic alopecia?Metformin has been shown to lower circulating androgens in women with PCOS, but no published study has measured scalp DHT, 5-alpha reductase activity in the follicle, or hair density in anyone taking it — so its effect on pattern hair loss is untested, and it is not a DHT blocker.