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research Male Senescence Phenotypes Include Hair Loss and Hair Gain

August 2026 in “Cureus”

This study found that higher scores of hair loss on the Hamilton-Norwood scale correlated with increased hair gain in the conchal bowl in men, suggesting potential age-related adaptations beyond cosmetic concerns.

research Weight Gain and Hair Loss during Anti-TNF Therapy

16 citations , January 2012 in “International Journal of Rheumatology”

In this study, weight gain and hair loss were reported as adverse effects of anti-TNF therapy in patients with rheumatic diseases, leading some to discontinue treatment.

research Efficacy and Tolerability of Hairgain® in Individuals with Hair Loss: A Placebo-Controlled, Double-Blind Study

18 citations , February 2001 in “Journal of International Medical Research”

In this study, a marine protein-based agent improved hair growth in subjects with various types of hair loss over a 12-month period, with good tolerability and no reported side effects.

research Hair Loss Caused by Gain-of-Function Mutant TRPV3 Is Associated with Premature Differentiation of Follicular Keratinocytes

11 citations , March 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that hair loss in an Olmsted syndrome mouse model with a Trpv3 mutation was linked to premature keratinocyte maturation, affecting hair follicle structure and function.

research 889 Trpv3 gain-of-function mutation impairs differentiation of hair follicle inner root sheath

April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, the researchers introduced a mutation in mice to mimic Olmsted syndrome and found that the mutation caused hair loss due to impaired keratinocyte differentiation and depletion of hair follicle stem cells.

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Community Join

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community Hair gained from micro needling, does it eventually get thicker?

in Microneedling 11 upvotes 3 years ago

User on Finasteride and Minoxidil saw minimal regrowth, tried micro needling with derma pen and noticed thin hair regrowth. Asks if micro needling hair gets thicker eventually.

community Are permanent hair gains even possible?

in Chat 13 upvotes 1 year ago

Hair regrowth from treatments like minoxidil, RU58841, and finasteride is not permanent; stopping these treatments typically results in hair loss resuming. Beard hair can become permanent with minoxidil use, unlike scalp hair, which requires ongoing treatment to maintain gains.

community Huge gains after catching hair loss it early

in Progress Pictures 956 upvotes 1 year ago

The user achieved significant hair regrowth using dutasteride 0.5mg for a year and oral minoxidil 2.5mg for eight months, despite initial shedding. They reported no side effects and preferred oral treatments over topicals.

community Gaining back lost hair on fin (due to fin)?

in Finasteride/Dutasteride 6 upvotes 8 months ago

The conversation discusses hair loss treatment with finasteride, where the user is experiencing shedding and concerns about regrowth. Users advise patience, suggesting that visible improvement may take 6-12 months or longer, and recommend continuing the treatment.

community Keeping ru58841 hair gains with only finasteride

in Finasteride/Dutasteride 13 upvotes 3 years ago

A user started using RU58841 before finasteride for hair loss and is now considering stopping RU58841 while continuing finasteride. They are asking if others have maintained hair gains from RU58841 after stopping it, but one response suggests it's risky to stop RU58841 if they want to keep their hair gains.

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Learn

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learn Valproic acid

What is valproic acid, and how did it become a subject of interest in hair growth and alopecia research? Valproic acid is a prescription anticonvulsant that laboratory and mouse studies link to the Wnt/β-catenin hair-growth pathway; one small randomized trial of an 8.3% topical spray reported a hair-count gain over 24 weeks. Oral valproate is also a recognized cause of hair loss and a known teratogen.

learn Botox

What’s the science behind Botox injections for androgenetic alopecia? Small published studies and a 2025 meta-analysis report hair-count gains from scalp botulinum toxin injections, but nearly all of them lack control groups, and reviewers of the same literature call the evidence low-quality; the treatment is off-label and not approved for hair loss anywhere.

learn Adenosine

nucleoside used for hair regrowth stimulant properties

learn Procyanidin

bioflavonoid found in plants with antioxidant and hair stimulating properties

learn Cetirizine

popular antihistamine showing promise for hair loss as an anti-inflammatory and prostaglandin inhibitor

learn Microneedling

technique to create small wounds in skin to activate collagen production and hair growth

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn GT20029

When will GT20029 be commercially available, and are there any clinical trials on its use? GT20029 is not approved or commercially available anywhere and remains investigational. A published 12-week Phase II study in 180 Chinese men reports hair-count gains over placebo, but no long-term or Phase III data exists, so any launch is years away at best.

learn Hair Fibers

Do hair fibers really make thinning hair look fuller, or is it just an illusion? Hair fibers create an optical illusion of fullness but do not actually thicken hair.
How do you apply hair fibers correctly so they stay in place all day? Apply hair fibers to clean, dry hair and use a setting spray for better hold.

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Clinics

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