In this study, researchers observed that apoptosis occurs in both growing and regressing hairfollicles in dogs, indicating a spatio-temporal relationship with the hair cycle.
In this study using live mice, researchers observed that during hairfollicle regression, apoptosis in basal cells may propagate by triggering neighboring cells, potentially regulated by a gradient of pro-survival signals from stem cells, and proposed a testable mechanism to further explore this process.
April 2023 in “Journal of Investigative Dermatology”
This study found that blocking apoptosis during the catagen phase in mice disrupts hairfollicle stem cell niche architecture, delaying subsequent hair regeneration cycles.
November 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”
This study in live mice suggests that hairfollicle regression involves apoptosis propagation towards stem cells, potentially slowed by a protective signal from the stem cells themselves.
Microneedling at depths greater than 0.6 mm may damage miniaturized hairfollicles, with 0.5 mm showing better results for hair regrowth. Combining microneedling with minoxidil enhances absorption, but caution is advised to avoid damaging follicles.
Mallia Aesthetics has developed MAL-838, a hormone-free product derived from sCD83, which stimulates hair growth without disrupting the skin microbiome. sCD83 promotes hair growth by activating hairfollicles and preventing celldeath, offering a localized treatment without systemic side effects.
A peptide from Japanese water chestnut fruit may help with hair loss by suppressing DHT's effect on hairfolliclecelldeath, potentially serving as a finasteride alternative. The treatment's effectiveness and safety in humans remain uncertain.
MCL-1 is important for hairfollicle stem cell survival, but its impact on human hair regrowth is unclear. Minoxidil and finasteride are the main treatments, with doubts about new discoveries leading to effective human solutions soon.
Stem cell and PRP therapy for hair loss is considered experimental and not consistently effective. Treatments like finasteride, minoxidil, and hair transplants are more established, but the potential for cloning chemically resistant hairfollicles is seen as a promising future solution.
How often should sulforaphane-based products be used for hair loss prevention?No human trial has tested sulforaphane for hair loss prevention, so there is no established usage frequency. Oral supplements are taken daily in research on unrelated conditions and the hair-specific evidence is limited to cell, mouse and isolated-follicle studies, so any schedule is extrapolation rather than a dosing guideline.