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Glossary Fibrous Protein

Fibrous proteins are structural proteins characterized by their elongated, thread-like shapes, which provide support and strength to various biological tissues. In the context of hair biology, keratin is the primary fibrous protein found in hair strands, contributing to their resilience and durability. These proteins are crucial for maintaining the integrity of hair follicles and overall hair structure, making them relevant in discussions of hair loss and disorders affecting hair health. Key distinguishing characteristics of fibrous proteins include their insolubility in water and their ability to form strong, stable structures.

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research Immunological characteristics and histological distribution of human hair fibrous proteins studied with anti-hair keratin monoclonal antibodies HKN-2, HKN-4, and HKN-6.

52 citations , February 1986 in “Journal of Histochemistry & Cytochemistry”

This study found that monoclonal antibodies can identify specific immunological characteristics of hair fibrous proteins, with some antibodies reacting only with hair proteins and others showing broader activity with skin and epithelial cells.

research Amino Acid Compositions of Human Hair Fibrous Protein Components Purified with Two‐dimensional Electrophoresis

4 citations , December 1989 in “The Journal of Dermatology”

This study suggests that the amino acid composition of fibrous proteins in normal human hair is similar to that of stratum corneum proteins, particularly in cysteine and glycine content.

research Two-dimensional electrophoretic analysis of human hair keratins, especially hair matrix proteins

10 citations , January 1989 in “Archives of Dermatological Research”

The method effectively analyzes human hair proteins, especially nonfilamentous ones.

research Content of Citrulline and Other Amino-Acids in a Protein of Hair Follicles

88 citations , July 1958 in “Nature”

This study reported the first known occurrence of citrulline in an animal protein, specifically in the fibrous protein of hair follicle inner root sheaths.

research Electrophoretic analysis of human hair keratins

4 citations , December 1995 in “Anthropologischer Anzeiger”

This study reports that electrophoretic patterns of hair keratins are more similar among family members than unrelated individuals, potentially aiding genetic studies.

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community Sugar and Hair loss connections

in Research/Science 41 upvotes 1 year ago

High sugar diets may worsen hair loss by increasing 5α-reductase activity and androgen levels, especially in women with PCOS. A low sugar diet might reduce scalp DHT levels, similar to finasteride, but genetics also significantly influence hair loss.

community Any improvement? Only dietary changes, Nizoral shampoo, micro needling and massage w/ rosemary essential oils. I’ve tried to get the same angle and lighting to make the best comparison picture. Any thoughts or advice would be much appreciated.

17 upvotes 5 years ago

The user reported slight hair improvement using dietary changes, Nizoral shampoo, microneedling, and rosemary oil massages. They avoided medications like minoxidil and finasteride due to side effects concerns.

community I have a hard time believing that creatine overpowers fin/dut

108 upvotes 3 years ago

The conversation is about whether creatine causes hair loss in individuals who are taking finasteride or dutasteride for hair loss. Some users report experiencing hair loss when taking creatine, while others do not. There is no consensus on the issue.

community PP405 Won’t Work: Follicle Is Miniaturized, Fibrosed, And Missing Key Support Cells

7 months ago

PP405 is ineffective for miniaturized, fibrosed hair follicles in androgenetic alopecia. AMP303 may activate hair follicle stem cells, but minoxidil and finasteride are still the main treatments.

community "Hair Follicle Stem Cells are quiescent 99% of the time and permanently reside in the hair follicle"

in Research/Science 1391 upvotes 1 year ago

Hair follicles are mostly dormant but can be reactivated with treatments like minoxidil, finasteride, and microneedling. A new drug, PP405, shows promise for hair regrowth but may not be available until 2027-2028.

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