TLDR Family members have similar hair protein patterns, which could be useful for genetic studies.
The study conducted electrophoretic analysis of non S-carboxymethylated human keratins extracted from the hair of individuals from 3 Italian families. Using SDS-PAGE and isoelectric focusing (IEF), hair fibrous proteins (HFP) were separated into polypeptide bands with molecular weights of 52 KDa, 44 KDa, and 40 KDa, and isoelectric points ranging from pH 7.4 to 4.0. Hair matrix proteins (HMP) were separated by IEF into bands with isoelectric points from pH 7.4 to 5.4, but could not be characterized by SDS-PAGE due to low concentration. Total extracted hair keratins showed additional bands at 16 KDa and 12 KDa. No interindividual variability was observed in electrophoretic patterns, except for one woman possibly affected by cosmetic treatment. Family members exhibited more similar patterns than unrelated individuals, suggesting that electrophoretic analysis of hair keratins could aid in genetic studies.
90 citations
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July 1993 in “Journal of Investigative Dermatology” 10 citations
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January 1989 in “Archives of Dermatological Research” The method effectively analyzes human hair proteins, especially nonfilamentous ones.
11 citations
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January 1987 in “Electrophoresis” Keratin proteins are consistent across different hair types from the same person.
15 citations
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January 1987 in “Electrophoresis” Human head hair proteins can be typed into eight distinct patterns, useful for genetic and forensic investigations.
356 citations
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356 citations
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Human hair keratins can self-assemble and support cell growth, useful for biomedical applications.
54 citations
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January 2018 in “Scientific reports” Human hair contains diverse proteins, including keratins and histones, which could help assess hair health and aging.
7 citations
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July 2019 in “International Journal of Molecular Sciences” PGA-4HGF may help treat hair loss by activating hair growth pathways and extending the hair growth phase.
Keratin hydrogels from human hair show promise for tissue engineering and regenerative medicine.
