TLDR Family members have similar hair protein patterns, which could be useful for genetic studies.
The study conducted electrophoretic analysis of non S-carboxymethylated human keratins extracted from the hair of individuals from 3 Italian families. Using SDS-PAGE and isoelectric focusing (IEF), hair fibrous proteins (HFP) were separated into polypeptide bands with molecular weights of 52 KDa, 44 KDa, and 40 KDa, and isoelectric points ranging from pH 7.4 to 4.0. Hair matrix proteins (HMP) were separated by IEF into bands with isoelectric points from pH 7.4 to 5.4, but could not be characterized by SDS-PAGE due to low concentration. Total extracted hair keratins showed additional bands at 16 KDa and 12 KDa. No interindividual variability was observed in electrophoretic patterns, except for one woman possibly affected by cosmetic treatment. Family members exhibited more similar patterns than unrelated individuals, suggesting that electrophoretic analysis of hair keratins could aid in genetic studies.
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