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GlossaryIntestinal Stem Cells (gut stem cells)

specialized cells in the gut that regenerate intestinal lining

Intestinal Stem Cells (ISCs) are specialized cells located in the lining of the intestines that have the ability to self-renew and differentiate into various types of cells that make up the intestinal epithelium. These cells are crucial for maintaining the integrity and function of the gut by continuously replenishing the intestinal lining, which is constantly being worn down by digestive processes.

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research Somatic Stem Cell Heterogeneity: Diversity in the Blood, Skin, and Intestinal Stem Cell Compartments

137 citations, April 2015 in “Nature Reviews Molecular Cell Biology”

Different types of stem cells with unique roles exist in blood, skin, and intestines, and this variety is important for tissue repair.

research Research Highlights: Latest Articles in Regenerative Medicine

7 citations, July 2012 in “Regenerative Medicine”

New treatments for diabetes, central nervous system repair, and cartilage injury were found, and a way to create functional hair follicles from stem cells was developed.

research Tp63-Expressing Adult Epithelial Stem Cells Cross Lineage Boundaries Revealing Latent Hairy Skin Competence

8 citations, November 2020 in “Nature Communications”

Adult stem cells with Tp63 can form hair and skin cells when placed in new skin, showing they have hidden abilities for skin repair.

research Stem Cells and the Niche: A Dynamic Duo

333 citations, February 2010 in “Cell Stem Cell”

Stem cell niches are crucial for regulating stem cell behavior and tissue health, and their decline can impact aging and cancer.

research Metabolic Regulation of Stem Cells in Aging

1 citations, April 2021 in “Current Stem Cell Reports”

Eating less can improve stem cell function and increase lifespan.

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community Fun thought experiment about halting hair loss permamently

in Research/Science 58 upvotes 6 months ago

A user proposed genetically engineering scalp stem cells to stop androgen receptors from causing hair loss. Others discussed the feasibility, existing research, and potential issues with this approach, including targeting the correct cells and unintended effects.

community Do you believe there will be a game changing treatment in the next 10 years?

in Chat 67 upvotes 2 years ago

Users discuss potential game-changing hair loss treatments in the next 10 years. Some mention KX-826, SCUBE3, and stem cells as promising options, while others express doubt due to past disappointments and lack of focused research.

community Is There Any Chance Of Cancer In Follicle Neogenesis through Microneedling?

in Microneedling 16 upvotes 4 years ago

The conversation discusses concerns about the potential risk of cancer from creating new hair follicles through microneedling, due to stem cell division. Specific treatments mentioned include microneedling, caffeine-containing anti-hair loss shampoos, and other unspecified topicals.

community Dr. Bloxham's Verteporfin Trial

in Research/Science 29 upvotes 1 year ago

Dr. Bloxham's trial is testing verteporfin on hair transplant patients to see if it can improve hair regrowth in treated areas. People are discussing the potential for follicle regeneration, expected results timeline, and concerns about side effects like cancer.

community New drug for hair loss announced by Amplifica

in Research/Science 161 upvotes 1 year ago

Amplifica starting clinical trials for new hair loss drug. SCUBE3 protein discovered, stimulates hair growth, could be alternative to Minoxidil and Finasteride.

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