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Glossary Growth Factor Signaling

process where proteins trigger cellular growth and repair

Growth Factor Signaling refers to the process by which certain proteins, known as growth factors, bind to specific receptors on the surface of cells, triggering a cascade of biochemical reactions inside the cell. This signaling pathway is crucial for regulating various cellular activities, including growth, division, and differentiation, and plays a significant role in tissue repair and development. For example, in the context of hair growth, specific growth factors can stimulate hair follicle cells to enter the growth phase, promoting hair regeneration.

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Research

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Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

research Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth-Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

136 citations , May 2019 in “Cells”

This review discusses the advancements in intraoperative stem cell therapies and highlights their potential to improve hair regrowth, but it reports no new clinical results.

Transforming Growth Factor-β Signaling-Mediated Wound Healing Is Required for Hair Follicle Neogenesis

research 484 Transforming growth factor-β signaling-mediated wound healing is required hair follicle neogenesis

November 2024 in “Journal of Investigative Dermatology”

TGF-β signaling is essential for new hair growth after wounds.

research Mathematical Modeling and Inference of Epidermal Growth Factor-Induced Mitogen-Activated Protein Kinase Cell Signaling Pathways

3 citations , September 2024 in “International Journal of Molecular Sciences”

This review examines how mathematical modeling of the MAPK pathway, enhanced by single-cell proteomic data, improves understanding of regulatory mechanisms, predicts system behavior, and guides experimental research, emphasizing recent developments in modeling and inference.

research Epidermal Growth Factor Promotes Proliferation and Migration of Follicular Outer Root Sheath Cells via Wnt/β-Catenin Signaling

43 citations , January 2016 in “Cellular physiology and biochemistry”

This study reports that EGF at specific concentrations promotes the proliferation and migration of hair follicle ORS cells by activating the Wnt/β-catenin signaling pathway in vitro.

research Epidermal Growth Factor Induces Proliferation of Hair Follicle-Derived Mesenchymal Stem Cells Through Epidermal Growth Factor Receptor-Mediated Activation of ERK and AKT Signaling Pathways Associated with Upregulation of Cyclin D1 and Downregulation of p16

83 citations , October 2016 in “Stem Cells and Development”

This study found that epidermal growth factor significantly enhances the proliferation of hair follicle-derived mesenchymal stem cells through the EGFR/ERK and AKT pathways, without involving the STAT3 pathway.

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Learn

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learn Platelet-Rich Plasma

What is Platelet-Derived Growth Factor Beta Polypeptide, and how does it help stimulate new hair growth? PDGF-BB is a growth factor that signals to dermal papilla cells and promotes blood-vessel formation; mouse studies report it can push follicles into the growth phase, and human evidence comes only indirectly from PRP trials. No PDGF product is approved for hair restoration and there is no published human trial of PDGF-BB on its own.

learn Stem Cell Factor

What is stem cell factor and why is it used in hair growth treatments? Stem cell factor promotes hair growth by signaling cell survival and division.

learn Epidermal Growth Factor

learn Exosomes

Microscopic delivery system that sends growth-promoting signals to hair follicles

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Follistatin

glycoprotein that inhibits TGF-β and promotes hair growth by antagonizing activin

learn Vascular Endothelial Growth Factor

What is Vascular Endothelial Growth Factor (VEGF), and how does it support hair growth in alopecia? VEGF promotes hair growth by enhancing blood supply to hair follicles.
Can products that stimulate Vascular Endothelial Growth Factor (VEGF) improve blood flow to hair follicles? Yes, products that stimulate VEGF may improve blood flow to hair follicles.
Is Vascular Endothelial Growth Factor (VEGF) available as a topical treatment, or is it only stimulated indirectly? VEGF is not available as a topical treatment for hair loss.

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Community Join

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community Calecim (PTT-6) Advanced Hair System with Topical Exosomes and Growth Factors for Hair Growth

1 year ago

Calecim (PTT-6) Advanced Hair System is a 6-week hair restoration product using stem cell-derived ingredients to stimulate hair growth. Users are skeptical, calling it overpriced and ineffective, suggesting alternatives like LLLT devices or PRP treatments.

community New angles to attack beyond DHT

4 upvotes 2 years ago

Exploring hair loss treatments beyond DHT, including Minoxidil, pyruvate, Gt20029 targeting androgen receptors, and vasodilators. Other options like Kx826, adenosine signaling, growth factor topicals, and microneedling are also discussed.

community Scalp hydration's surprising link to hair growth cycle regulation

in Technology 23 upvotes 4 months ago

Scalp hydration may influence hair growth by affecting the signaling pathways that control the hair growth cycle. Users suggest using facial moisturizer, aloe vera, and oils for scalp hydration.

community DHT Isn’t the Only Factor in Hair Loss and That Might Be the Key to a Real Cure

373 upvotes 6 months ago

Hair loss involves more than just DHT, with genetic factors like TRPS affecting hair follicles. Treatments such as Amplifica's AMP-601 and AMP-303 target stem cells for potential hair growth solutions.

community Weed/THC effects on hair growth/hair loss, and vitality of organ-culture human follicle studies (research review)

4 upvotes 1 year ago

Cannabis and THC may have mixed effects on hair, with some studies suggesting potential negative impacts on hair growth in isolated hair follicles, but these results are hard to apply to living humans. Treatments like minoxidil and finasteride are commonly used for hair loss, and the effects of cannabis might be neutral or vary based on individual factors.

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