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GlossaryGonadotropin-Releasing Hormone Antagonists (GnRH blockers)

medications that block hormone signals to reduce sex hormone production

Gonadotropin-Releasing Hormone Antagonists (GnRH antagonists) are medications that block the action of GnRH, a hormone responsible for stimulating the release of other hormones like LH and FSH from the pituitary gland. By inhibiting this pathway, GnRH antagonists can reduce the production of sex hormones such as testosterone and estrogen, making them useful in treatments for conditions like prostate cancer, endometriosis, and certain fertility issues.

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Medical Care for Children and Adolescents with Gender Dysphoria and Gender Inconsistency in Light of Current Recommendations: How to Implement the 'Primum Non Nocere' Principle?

research Medical Care for Children and Adolescents with Gender Dysphoria and Gender Inconsistency in Light of Current Recommendations: How to Implement the 'Primum Non Nocere' Principle?

September 2023 in “Fides et Ratio”

The safety and effectiveness of gender-affirming treatments for children are uncertain, with potential long-term risks like infertility.

research 5-Alpha-Reductase Inhibitors Are Associated With Reduced Frequency of COVID-19 Symptoms in Males With Androgenetic Alopecia

36 citations, November 2020 in “Journal of The European Academy of Dermatology and Venereology”

5-alpha-reductase inhibitors may reduce COVID-19 symptoms in bald males.

research Endocrinology, Brain, and Pituitary Gland

2 citations, November 2013 in “Elsevier eBooks”

Hormones control reproduction and are crucial for body balance.

research Hormonal Therapies for Acne

26 citations, October 2016 in “Clinics in Dermatology”

Hormonal treatments can improve acne, but they come with potential side effects and risks.

research Hormone Therapy in Acne

24 citations, January 2013 in “Indian Journal of Dermatology, Venereology and Leprology”

Hormonal treatment is effective for women with acne not helped by usual treatments, especially if they have hormonal imbalances.

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community 35 MtF | 16 Months | Minoxidil + Dutasteride + Microneedling + Exosomes. Note that since I'm early in my transition (and I was coming from a bald state), I still have short hair. Very few MtF progress pictures here, I figure this might help some of you.

in Transgender 129 upvotes 10 months ago

A 35-year-old transitioning female (MtF) shared her hair regrowth journey using Minoxidil, Dutasteride, Microneedling, and Exosomes, starting from a bald state. Commenters discussed the impressive results, skin care routine, and the effects of estrogen on hair and skin.

community Physician here AMA – 30M oral Fin 1-1.25 mg daily

in Update 47 upvotes 2 years ago

Hair loss treatments, specifically the use of finasteride, microneedling and potentially oral minoxidil. People discussed their experiences with finasteride, its effects on sexual behaviors, as well as potential solutions such as tadalafil or using other growth factor signal peptides for hope in curing male pattern baldness.

community My Testosterone is less than 1/3rd In 7 Months since I took Finasteride!

in Finasteride/Dutasteride 113 upvotes 1 year ago

A user experienced a significant drop in testosterone levels after taking finasteride, leading to side effects like low libido and muscle mass loss. Despite its effectiveness for hair, the user decided to stop finasteride due to its impact on hormones, preferring to be bald.

community Insane MTF recovery 18 months blocking androgens

in Progress Pictures 145 upvotes 1 year ago

Hair loss recovery using estrogen and anti-androgen treatment for 18 months showed significant improvement. However, results vary and alternative treatments like RU58841 and Dutasteride may work without systemic feminization.

community Two Great Articles on NCBI That Summarize What We Actually Know About Finasteride Side Effects

in Finasteride 80 upvotes 5 years ago

The side effects of taking finasteride as a treatment for hair loss, with particular focus on its sexual and psychiatric side effects; research has indicated that there are high and low outliers in terms of prevalence of sexual side effects, but it is usually between 3-5%, while evidence of lasting sexual side effects comes from lower quality sources.