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GlossaryGABAA Receptors

ion channels in the brain that reduce neuronal excitability

GABAA receptors, also known as Gamma-Aminobutyric Acid Type A receptors, are a class of receptors in the brain that respond to the neurotransmitter GABA, the primary inhibitory neurotransmitter in the central nervous system. These receptors are ion channels that, when activated, allow chloride ions to enter the neuron, making it less likely to fire and thus reducing neuronal excitability. This mechanism is crucial for regulating brain activity and is a target for various medications, including sedatives, anxiolytics, and anticonvulsants.

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learn Valproic acid

an anticonvulsant repurposed for hair loss via histone inhibition

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research Brain Allopregnanolone Induces Marked Scratching Behavior in Diet-Induced Atopic Dermatitis Mouse Model

6 citations , February 2019 in “Scientific reports”

A brain-produced steroid causes increased scratching in mice with a skin condition similar to eczema.

research Studies on Neurosteroids XXV: Influence of a 5α-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism

61 citations , September 2008 in “Biological & Pharmaceutical Bulletin”

Finasteride almost fully depletes allopregnanolone in rat brains and enhances 20α-DHP, but doesn't change 3α-DHP levels.

research Nucleus-Specific Modulation of Phasic and Tonic Inhibition by Endogenous Neurosteroidogenesis in the Murine Thalamus

November 2019 in “Synapse”

Brain-made chemicals can control nerve cell function differently in various parts of a mouse's brain, which may help us understand neurological conditions.

research Role of Anticonvulsant and Antiepileptogenic Neurosteroids in the Pathophysiology and Treatment of Epilepsy

65 citations , January 2011 in “Frontiers in Endocrinology”

Neurosteroids show promise for treating epilepsy and more research is needed.

Treatment With and Withdrawal From Finasteride Alter Ethanol Intake Patterns in Male C57BL/6J Mice: Potential Role of Endogenous Neurosteroids

research Treatment With and Withdrawal From Finasteride Alter Ethanol Intake Patterns in Male C57BL/6J Mice: Potential Role of Endogenous Neurosteroids

54 citations , August 2005 in “Alcohol”

Finasteride affects alcohol intake in male mice, possibly due to neurosteroids.

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community 23M Couldn’t go bald for fear of my Girlfriend leaving me.

in Is this regrowth? 1089 upvotes 2 months ago

A 23-year-old man uses a topical spray with minoxidil, finasteride, and tretinoin for hair loss, experiencing improved hair growth but occasional heart palpitations. He worries his girlfriend might leave him if he goes bald, but commenters advise that if she would leave over hair loss, she isn't worth it.

community Horrible news, Stemson Therapeutics has shut down

in Technology 193 upvotes 9 months ago

Stemson Therapeutics has shut down, disappointing those seeking a hair loss cure. Current treatments like minoxidil, finasteride, and dutasteride are discussed, with some users experiencing side effects and exploring alternatives like PP405.

community Kintor’s KX-826 Pyrilutamide!!

in Research/Science 153 upvotes 3 years ago

KX-826 hair loss treatment completed trials with mild side effects. GT20029 may be ultimate cure, destroying androgen receptors causing baldness.

community Can we stop fear mongering with finasteride

in Finasteride/Dutasteride 224 upvotes 2 days ago

Finasteride is effective for hair loss but can cause sexual dysfunction and mental health issues in some users, leading to a polarized debate on its risks. Some switch to alternatives like Dutasteride or topical treatments to avoid side effects.

community Don't fall for the fear mongering bros

in Satire 1528 upvotes 4 months ago

Hair loss treatments discussed include finasteride, minoxidil, spironolactone, and estradiol, with concerns about side effects like sexual dysfunction and feminization. Some users prefer hair transplants or shaving over medication due to potential side effects.

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