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research Thrombospondin-1 Plays a Critical Role in the Induction of Hair Follicle Involution and Vascular Regression During the Catagen Phase

52 citations , January 2003 in “Journal of Investigative Dermatology”

This study found that thrombospondin-1 plays a critical role in hair follicle cycle regulation, with deficiency prolonging follicle growth and overexpression delaying it through antiangiogenic effects.

research Dihydrotestosterone-Inducible IL-6 Inhibits Elongation of Human Hair Shafts by Suppressing Matrix Cell Proliferation and Promotes Regression of Hair Follicles in Mice

173 citations , September 2011 in “Journal of Investigative Dermatology”

IL-6 contributes to hair loss by shortening the growth phase and causing hair follicles to regress.

research Human Scalp Hair Follicles Are Both a Target and a Source of Prolactin, which Serves as an Autocrine and/or Paracrine Promoter of Apoptosis-Driven Hair Follicle Regression

128 citations , March 2006 in “American Journal of Pathology”

The study found that prolactin expressed in human scalp hair follicles acts as an autocrine modulator, inhibiting hair growth and promoting hair follicle regression, which may contribute to hair loss in hyper-prolactinemia patients.

research A Murine Model for Inducing and Manipulating Hair Follicle Regression (Catagen): Effects of Dexamethasone and Cyclosporin A

124 citations , August 1994 in “Journal of Investigative Dermatology”

This study found that applying dexamethasone to mice induced catagen-like follicle changes significantly earlier and more consistently than a vehicle, such changes being useful for studying hair follicle regression.

research A role for p75 neurotrophin receptor in the control of apoptosis‐driven hair follicle regression

96 citations , October 2000 in “The FASEB Journal”

In this study, researchers found that p75 neurotrophin receptor signaling affects apoptosis during hair follicle regression in mice, and altering its activity might help manage disorders involving early catagen entry.

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Community Join

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community Insane regression after hyper-responding (17M) AMA

in Progress Pictures 137 upvotes 1 year ago

A 17-year-old experienced significant hair loss after switching from topical to oral minoxidil and adding finasteride. The recommendation is to return to topical minoxidil and continue with finasteride or consider dutasteride.

community Natural Techniques for Light / Moderate Recession

1 upvotes 1 year ago

The user experienced hair regrowth and stabilization at Norwood 2 using natural remedies like pumpkin seed oil, rosemary oil, vitamins, and scalp massages, avoiding minoxidil and finasteride due to side effects. Another user suggested starting topical finasteride earlier to prevent further hair loss.

community Regression? Has anyone experienced this?

in Progress Pictures 46 upvotes 1 year ago

The user is experiencing increased hair shedding and is concerned about regression despite consistent use of finasteride, minoxidil, and other treatments. The consensus is that this is likely a temporary shedding phase, and adjustments to the dermarolling frequency are suggested.

community Is finasteride enough for diffuse thinning without recession?

in Finasteride/Dutasteride 19 upvotes 1 year ago

Finasteride may be sufficient for diffuse thinning, but dutasteride is generally considered more effective, with a higher chance of hair growth. Adding oral minoxidil can improve results, though some users report side effects.

community Do hair follicles dies or are dormant ?

in Finasteride/Dutasteride 92 upvotes 1 year ago

Hair follicles can be dormant and potentially revived with treatments like finasteride and minoxidil, but irreversible loss occurs if certain structures are destroyed. Early intervention is more effective, and additional methods like microneedling may help.

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Learn

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learn retinol

How often should retinol scalp treatments be used to see improvement without over-exfoliating? No study has worked out a safe or effective frequency for retinol on the scalp, and lab studies show retinoic acid can push hair follicles into early regression (catagen). Ask a dermatologist, and avoid retinoids in pregnancy.

learn Follicusan

learn Exosomes

Tiny cell-derived particles offered by clinics as an injectable treatment

learn Niacinamide

Does niacinamide support hair follicle nutrition? Niacinamide is a precursor of NAD+, a molecule cells use for energy. Whether it affects hair follicles in people has not been tested.

learn Scalp Micropigmentation

Will scalp micropigmentation damage my existing hair or follicles? Providers say SMP sits above the hair follicles and does not harm them. No study has tested this, and infection or scarring from any tattoo can affect the skin.

learn Redensyl

Does Redensyl regenerate follicles or only strengthen existing hair? No independent study has shown that Redensyl regenerates follicles or strengthens hair; the only human data are a small, unpublished manufacturer study.

learn Sulforaphane

Can sulforaphane protect hair follicles from inflammation and damage? In lab and mouse studies, sulforaphane reduced markers of inflammation and oxidative stress. No human study has tested whether it protects hair follicles.

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