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community Enlighten me about the role of ethanol and PG in topical solutions, where the ideal ratio of the two is, and why?

2 upvotes 10 months ago

The conversation discusses the use of ethanol and propylene glycol (PG) in topical solutions for hair loss treatments, specifically Minoxidil. The user dislikes the texture of PG and questions the ideal ratio and necessity of PG in these solutions.

community RU and cetosomal minoxidil topical

1 upvotes 7 months ago

Mixing RU58841 with cetosomal minoxidil is discussed due to scalp irritation from ethanol PG vehicles. A mixture of the two turned bright pink when left to dry.

community Are we underestimating systemic absorption with homemade/generic Topical Fin? (HPCH vs. PG/Ethanol formulations)

5 upvotes 7 months ago

Topical finasteride may have higher systemic absorption and lower efficacy when using a Propylene Glycol/Ethanol formulation compared to the hydroxypropyl chitosan (HPCH) formulation. The safety profile of topical finasteride relies heavily on the HPCH formulation, and using standard solutions might lead to different pharmacokinetics.

community Best way to go about making a DIY topical fin for someone who's allergic to PG?

1 upvotes 5 months ago

A user allergic to propylene glycol seeks alternatives for a DIY topical finasteride solution, considering glycerin or glycerol-based vehicles. Another user suggests a recipe using propanediol, DMSO, MCT oil, and peppermint oil, incorporating minoxidil, dutasteride, and finasteride.

community Best way to go about making a DIY topical fin for someone who's allergic to PG?

1 upvotes 5 months ago

The conversation discusses creating a DIY topical finasteride solution for someone allergic to propylene glycol, with suggestions to use glycerin or a glycerol-based vehicle instead. The user also mentions using foam minoxidil.

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Research

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research Skin permeation of curcumin nanocrystals: Effect of particle size, delivery vehicles, and permeation enhancer

15 citations , February 2023 in “Colloids and surfaces. B, Biointerfaces”

In this study using a porcine skin model, the researchers reported that smaller curcumin nanocrystals in xanthan gum gel showed higher passive skin penetration, while larger particles achieved deeper follicular accumulation.

research The Effect of Various Vehicles on the In Vitro Skin Permeability of Minoxidil

October 2022 in “Journal of Kermanshah University of Medical Sciences”

The researchers reported that caprylic acid effectively enhances the permeability and diffusion of minoxidil through rat skin compared to other penetration enhancers.

research Relative uptake of minoxidil into appendages and stratum corneum and permeation through human skin in vitro

55 citations , June 2009 in “Journal of Pharmaceutical Sciences”

This study found that ethanol-containing formulations significantly increased minoxidil retention in the stratum corneum and appendages initially, while a propylene glycol-rich formulation enhanced deeper skin penetration over time.

research Percutaneous Drug Delivery to the Hair Follicle

1 citations , July 2005 in “Informa Healthcare eBooks”

Hair follicles could be used for targeted drug delivery, with liposomal systems showing promise for this method.

research A comprehensive review on invasomal carriers incorporating natural terpenes for augmented transdermal delivery

26 citations , December 2022 in “Future Journal of Pharmaceutical Sciences”

This review discusses the use of terpenes and invasomes as permeation enhancers for transdermal drug delivery, focusing on their potential applications in pharmaceutical formulations, but it reports no new experimental results.

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Learn

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learn propylene glycol

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