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learn Estradiol

Estrogen hormone, prescribed in tablet, patch and gel forms

Why is Estradiol used to treat hair loss in women and transgender people undergoing hormone therapy? Estradiol is used within supervised hormone therapy and may slow hormone-related hair loss in some women and trans women, but the evidence is limited and it carries serious whole-body risks.
Is applying Estradiol directly to the scalp effective for hormone-related hair thinning? There are no good-quality trials showing that estradiol applied to the scalp treats hormone-related thinning. Skin-applied estradiol can still enter the bloodstream and pass to others through contact.
Does Estradiol only stop hair loss, or can it also help regrow hair? There is no good evidence that estradiol regrows hair on its own. Regrowth in trans women on testosterone-lowering therapy is described in case reports only.
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Research

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research Achieving Physiologic 17-ẞ-Estradiol Levels in Transgender Females on Estradiol Transdermal Patches and Optimal Dosing

May 2021 in “Journal of the Endocrine Society”

This study found that estradiol transdermal patches helped many MTF patients achieve target estrogen levels, especially those who could not reach these levels with oral therapy and those at higher thrombotic risk.

research Does Estradiol Level in Platelet-Rich Plasma Improve Efficacy of Androgenic Alopecia Treatment?

June 2020 in “Aesthetic Surgery Journal”

This study found that PRP with high estrogen levels increased hair density more effectively and earlier than autologous PRP in male patients with androgenic alopecia.

research Weak correlations between serum and cerebrospinal fluid levels of estradiol, progesterone and testosterone in males

19 citations , October 2019 in “BMC Neuroscience”

This study found weak to very weak correlations between estradiol, progesterone, and testosterone levels in the cerebrospinal fluid and serum of males without cerebral disorders.

research Puberty in Boys: Correlation of Plasma Levels of Gonadotropins (LH, FSH), Androgens (Testosterone, Androstenedione, Dehydroepiandrosterone and Its Sulfate), Estrogens (Estrone and Estradiol) and Progestins (Progesterone and 17-Hydroxyprogesterone)

96 citations , September 1975 in “The Journal of Clinical Endocrinology & Metabolism”

In this study, significant elevations of DHA and testosterone were associated with pubic hair development and voice changes in boys during puberty.

research Reduced serum vitamin B12 levels during oral cyproterone-acetate and ethinyl-oestradiol therapy in women with diffuse androgen-dependent alopecia

20 citations , July 1990 in “Clinical and experimental dermatology”

In this study, women treated for androgen-dependent alopecia with CPA EE2 therapy experienced significant decreases in serum vitamin B12, hemoglobin, and hematocrit levels after six months.

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Community Join

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community My Estradiol Level on Finasteride

18 upvotes 1 year ago

Finasteride has no effect on the user's estradiol levels, and body fat may influence aromatization. The user is on testosterone replacement therapy and uses everyday injections to manage high RBC count, with plans to measure DHT, DHEA-S, and pregnenolone levels.

community Going on what I’ve read fixing e2 (estradiol) levels should cure PFS (post finasteride syndrome)?

4 upvotes 4 years ago

Balancing estradiol (e2) levels may alleviate post-finasteride syndrome (PFS) symptoms. Hormone tests, including testosterone and e2, are recommended for those experiencing PFS.

community Testosterone and Estradiol levels on 1 mg/day dutasteride

43 upvotes 11 months ago

A 30-year-old man experienced significant hair regrowth and improved libido after using finasteride and dutasteride for androgenetic alopecia, with no adverse effects. He plans to reduce dutasteride dosage when trying to conceive and has been using topical minoxidil since 2015.

community How quickly does fin raise estradiol levels?

4 upvotes 1 year ago

Finasteride can quickly raise estradiol levels by blocking DHT, allowing testosterone to convert to estrogen. Taking finasteride for just a few days can affect blood test results.

community Estradiol (E2), Testosterone and DHT levels after 1 month on Dutasteride

in Research/Science 11 upvotes 1 year ago

Dutasteride and finasteride are used for hair loss, affecting hormone levels like DHT and testosterone. Hormone balance is crucial, as changes can lead to side effects such as increased estradiol and potential hair loss.

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