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Glossary Epidermal Layers

multiple strata of cells forming the skin's outermost part

Epidermal layers refer to the multiple strata of cells that make up the outermost part of the skin, known as the epidermis. These layers include, from the deepest to the most superficial, the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum (only in thick skin), and stratum corneum. Each layer has distinct functions, such as cell regeneration, protection against pathogens, and the formation of a barrier to prevent water loss.

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Research

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research Three-Dimensional Analysis of Cell Division Orientation in Epidermal Basal Layer Using Intravital Two-Photon Microscopy

31 citations , September 2016 in “PLoS ONE”

The researchers reported that in hairless mice, epidermal cell division orientations and epidermal thickness varied by body site, with dorsal and ear epidermis primarily dividing parallel to the basement membrane, unlike hind paw and tail epidermis.

research Krt6a-Cre Transgenic Mice Direct LoxP-Mediated Recombination to the Companion Cell Layer of the Hair Follicle and Following Induction by Retinoic Acid to the Interfollicular Epidermis

10 citations , January 2004 in “Journal of Investigative Dermatology”

Krt6a-Cre transgenic mice help study gene effects on hair follicle development and tumor suppression.

research Long-term follow-up of leucoderma patients treated with transplants of autologous cultured melanocytes, ultrathin epidermal sheets and basal cell layer suspension

177 citations , November 2002 in “British journal of dermatology/British journal of dermatology, Supplement”

In this study, stable types of leucoderma such as segmental vitiligo and piebaldism showed 100% repigmentation after melanocyte transplantation, suggesting surgery as the preferred method for these conditions.

research Bikunin, a Serine Protease Inhibitor, is Present on the Cell Boundary of Epidermis

13 citations , August 1999 in “Journal of Investigative Dermatology”

This study found that bikunin is expressed in human keratinocytes and may play a role in regulating keratinocyte function during mitosis or inflammation.

research A Niche Above: A Novel Modality of Stem Cell Regulation in Mammalian Skin Epidermis

March 2021 in “Cell stem cell”

This study found that actomyosin contractility in suprabasal keratinocytes influences the proliferation and differentiation of epidermal stem/progenitor cells by acting as a niche element in the skin.

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Learn

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learn Epidermal Growth Factor

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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Community Join

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community Keratin microspheres - breakthrough

14 upvotes 2 years ago

A gel of keratin microspheres promotes hair follicle growth, showing similar effectiveness to minoxidil in mice. The treatment activates hair growth pathways and reduces inflammation, with potential applications in drug delivery for hair-related disorders.

community Tazarotene shows strong standalone hair regrowth potential, not just a Minoxidil enhancer. Backed by VEGF, HF regeneration, and angiogenesis pathways. Here’s why.

135 upvotes 1 year ago

Tazarotene shows potential as a standalone treatment for hair regrowth by stimulating new hair follicle formation and promoting angiogenesis, similar to microneedling effects. It can be used topically without minoxidil, but users should start with a low concentration to avoid irritation.

community Why everyone should be using topical Dutasteride

45 upvotes 3 months ago

Topical Dutasteride, especially in a liposomal base, is recommended for enhanced scalp DHT suppression when used with oral Dutasteride. It is suggested to apply it twice a week for effective results without significant systemic impact.

community Comprehensive Microneedling Guide

292 upvotes 4 years ago

Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 1 year ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

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Layers

Graig Lauricella