TLDR Vitamin A during pregnancy can harm fetal skin development.
The study investigated the effects of retinoic acid (RA) on fetal skin when administered to pregnant albino mice. Twelve pregnant mice were divided into two groups, with the experimental group receiving 60 mg/kg/day of RA orally on days 7, 8, and 9 of gestation. Histological examination of the fetal skin from the RA-treated group revealed increased keratinocyte proliferation, resulting in more epidermal cell layers and greater epidermal thickness. Additionally, RA inhibited hair follicle development, which appeared as rudimentary buds in the dermis. The findings suggested that RA usage during pregnancy should be approached with caution due to its significant impact on fetal skin development.
31 citations,
September 2012 in “Journal of biological chemistry/The Journal of biological chemistry” The right amount of retinoic acid is essential for normal hair growth and development.
1113 citations,
August 1999 in “The New England Journal of Medicine” Hair follicle biology advancements may lead to better hair growth disorder treatments.
January 2018 in “Stem cell biology and regenerative medicine” The nucleus is key in controlling skin growth and repair by coordinating signals, gene regulators, and epigenetic changes.
148 citations,
October 2008 in “The journal of investigative dermatology/Journal of investigative dermatology” Mice without the vitamin D receptor are more prone to UV-induced skin tumors.
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July 2006 in “Endocrine Reviews” Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.
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10 citations,
September 1997 in “Molecular carcinogenesis” Mirex seems to promote a unique group of skin cells different from those affected by another tumor promoter, TPA.
