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    Glossary Eosinophilia-Myalgia Syndrome

    rare condition with high eosinophils and severe muscle pain

    Eosinophilia-Myalgia Syndrome (EMS) is a rare and potentially serious condition characterized by high levels of eosinophils (a type of white blood cell) in the blood and severe muscle pain (myalgia). It was notably linked to the consumption of contaminated L-tryptophan supplements in the late 1980s. Symptoms can include muscle weakness, skin changes, and joint pain, and the condition may lead to long-term health issues if not properly managed.

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    1. Scleroderma and L-tryptophan: A possible explanation of the eosinophilia-myalgia syndrome Journal of The American Academy of Dermatology · 1990 · 21 citations
    2. Cutaneous Mucinosis in a Patient With Eosinophilia-Myalgia Syndrome Associated With L-Tryptophan Ingestion Archives of Dermatology · 1990 · 11 citations
    3. Comparison of the Pathology of Fascia in Eosinophilic Myalgia Syndrome Patients and Idiopathic Eosinophilic Fasciitis Dermatology · 1993 · 11 citations
    4. Dermal Mucinosis in the Eosinophilia-Myalgia Syndrome Archives of Dermatology · 1990 · 8 citations
    5. Telogen effluvium associated with eosinophilia-myalgia syndrome Journal of The American Academy of Dermatology · 1991 · 5 citations
    6. The eosinophilia-myalgia syndrome Clinics in Dermatology · 1994 · 4 citations
    7. A patient with eosinophilia-myalgia syndrome. PubMed · 1990 · 1 citations
    8. Eosinophilic Fasciitis Associated With Tryptophan Ingestion Archives of dermatology · 1991 · 20 citations
    9. THERAPEUTIC CHALLENGES IN POLYAUTOIMMUNITY: ANIFROLUMAB FOR LUPUS ERYTHEMATODES IN OVERLAPPING AUTOIMMUNE SYNDROMES The Journal of Rheumatology · 2025
    10. MIXED CONNECTIVE TISSUE DISEASE EVOLVING FROM THE SEQUENTIAL OVERLAP OF SYSTEMIC LUPUS ERYTHEMATOSUS, SJÖGREN’S SYNDROME, RHEUMATOID ARTHRITIS AND DERMATOMYOSITIS: A FOLLOW-UP The Journal of Rheumatology · 2025
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