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Glossary Eosinophilia-Myalgia Syndrome

rare condition with high eosinophils and severe muscle pain

Eosinophilia-Myalgia Syndrome (EMS) is a rare and potentially serious condition characterized by high levels of eosinophils (a type of white blood cell) in the blood and severe muscle pain (myalgia). It was notably linked to the consumption of contaminated L-tryptophan supplements in the late 1980s. Symptoms can include muscle weakness, skin changes, and joint pain, and the condition may lead to long-term health issues if not properly managed.

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research Scleroderma and L-tryptophan: A possible explanation of the eosinophilia-myalgia syndrome

21 citations , September 1990 in “Journal of The American Academy of Dermatology”

This study reports that six women developed scleroderma while taking L-tryptophan and showed improvement after stopping the supplement and/or starting corticosteroid therapy.

research Cutaneous Mucinosis in a Patient With Eosinophilia-Myalgia Syndrome Associated With L-Tryptophan Ingestion

11 citations , November 1990 in “Archives of Dermatology”

This case report describes a patient with eosinophilia-myalgia syndrome, likely linked to L-tryptophan use, who developed a skin rash characterized by cutaneous mucinosis.

research Comparison of the Pathology of Fascia in Eosinophilic Myalgia Syndrome Patients and Idiopathic Eosinophilic Fasciitis

11 citations , January 1993 in “Dermatology”

In this study, researchers found histopathological similarities between L-tryptophan eosinophilic myalgia syndrome and idiopathic eosinophilic fasciitis, with certain unique inflammatory features present in the former.

research Dermal Mucinosis in the Eosinophilia-Myalgia Syndrome

8 citations , November 1990 in “Archives of Dermatology”

This case report details a woman with eosinophilia-myalgia syndrome associated with L-tryptophan ingestion, highlighting skin lesions with abundant dermal mucin.

research Telogen effluvium associated with eosinophilia-myalgia syndrome

5 citations , July 1991 in “Journal of The American Academy of Dermatology”

This case report describes a patient with eosinophilia-myalgia syndrome who experienced severe, persistent telogen effluvium.

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