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    Glossary Eosinophilia-Myalgia Syndrome

    rare condition with high eosinophils and severe muscle pain

    Eosinophilia-Myalgia Syndrome (EMS) is a rare and potentially serious condition characterized by high levels of eosinophils (a type of white blood cell) in the blood and severe muscle pain (myalgia). It was notably linked to the consumption of contaminated L-tryptophan supplements in the late 1980s. Symptoms can include muscle weakness, skin changes, and joint pain, and the condition may lead to long-term health issues if not properly managed.

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    1. Scleroderma and L-tryptophan: A possible explanation of the eosinophilia-myalgia syndrome Journal of The American Academy of Dermatology · 1990 · 21 citations
    2. Cutaneous Mucinosis in a Patient With Eosinophilia-Myalgia Syndrome Associated With L-Tryptophan Ingestion Archives of Dermatology · 1990 · 11 citations
    3. Comparison of the Pathology of Fascia in Eosinophilic Myalgia Syndrome Patients and Idiopathic Eosinophilic Fasciitis Dermatology · 1993 · 11 citations
    4. Dermal Mucinosis in the Eosinophilia-Myalgia Syndrome Archives of Dermatology · 1990 · 8 citations
    5. Telogen effluvium associated with eosinophilia-myalgia syndrome Journal of The American Academy of Dermatology · 1991 · 5 citations
    6. The eosinophilia-myalgia syndrome Clinics in Dermatology · 1994 · 4 citations
    7. A patient with eosinophilia-myalgia syndrome. PubMed · 1990 · 1 citations
    8. Eosinophilic Fasciitis Associated With Tryptophan Ingestion Archives of dermatology · 1991 · 20 citations
    9. MIXED CONNECTIVE TISSUE DISEASE EVOLVING FROM THE SEQUENTIAL OVERLAP OF SYSTEMIC LUPUS ERYTHEMATOSUS, SJÖGREN’S SYNDROME, RHEUMATOID ARTHRITIS AND DERMATOMYOSITIS: A FOLLOW-UP The Journal of Rheumatology · 2025
    10. Non‐infective mucocutaneous presentations of human immunodeficiency virus infection Australasian Journal of Dermatology · 1997 · 8 citations
    11. Dermatologic Manifestations of Human Immunodeficiency Virus Infection Mayo Clinic Proceedings · 1992 · 53 citations
    12. Drug-Induced Skin, Nail and Hair Disorders Drug Safety · 2007 · 114 citations
    13. Psychoactive drugs and skin Journal of the European Academy of Dermatology and Venereology · 2003 · 12 citations
    14. Metformin potential in predisposing arthralgia, type II cross reactivity secondary to group A streptococcus infection & other comorbidities in treating PCOS Pakistan Journal of Pharmaceutical Sciences · 2019
    15. Tinea capitis in adult women masquerading as bacterial pyoderma Journal of the American Academy of Dermatology · 2003 · 32 citations
    16. ASSOCIATION OF SYSTEMIC LUPUS ERYTHEMATOSUS AND CHRONIC GRANULOMATOUS DISEASE IN ADULTS: REPORT OF 2 CASES The Journal of Rheumatology · 2025
    17. Macrophage Activation Syndrome/Secondary Hemophagocytic Lymphohistiocytosis in Adult‐Onset Still's Disease: An Uncommon Initial Presentation in a Young Nepalese Female: A Case Report Clinical Case Reports · 2025
    18. Fatal Case of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Induced by Doxycycline or Flucloxacillin in a 77-Year-Old Woman: A Rare but Serious Adverse Drug Reaction Cureus · 2025
    19. Systemic-Onset Juvenile Idiopathic Arthritis with unusual Cutaneous Manifestation and peripheral eosinophilia: Case Report Authorea (Authorea) · 2023
    20. Skin manifestations associated with systemic diseases – Part I Anais Brasileiros de Dermatologia · 2021 · 11 citations
    21. Medical Dermatology Australasian Journal of Dermatology · 2024 · 2 citations
    22. Aldesleukin Elsevier eBooks · 2015
    23. Acne and acneiform eruptions Elsevier eBooks · 2011 · 2 citations
    24. Anthelminthic drugs Side effects of drugs annual · 1992
    25. Cytostatics and immunosuppressive drugs Side effects of drugs annual · 1989
    26. TONGUE, RED 2006
    27. Skin, mucosa and nail findings in hospitalized pediatric patients with Coronavirus disease-2019 (COVID-19) Anais Brasileiros de Dermatologia · 2022 · 1 citations
    28. ANIFROLUMAB IN THE MANAGEMENT OF LUPUS HEADACHES: A CASE REPORT The Journal of Rheumatology · 2025 · 1 citations
    29. A 25-year-old female with a variable presentation of MCTD-A case report 2024
    30. Levodopa-induced skin disorders in patients with Parkinson disease: a systematic literature review approach Acta Neurologica Belgica · 2019 · 12 citations