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    Glossary Eosinophilia-Myalgia Syndrome

    rare condition with high eosinophils and severe muscle pain

    Eosinophilia-Myalgia Syndrome (EMS) is a rare and potentially serious condition characterized by high levels of eosinophils (a type of white blood cell) in the blood and severe muscle pain (myalgia). It was notably linked to the consumption of contaminated L-tryptophan supplements in the late 1980s. Symptoms can include muscle weakness, skin changes, and joint pain, and the condition may lead to long-term health issues if not properly managed.

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    1. Scleroderma and L-tryptophan: A possible explanation of the eosinophilia-myalgia syndrome Journal of The American Academy of Dermatology · 1990 · 21 citations
    2. Cutaneous Mucinosis in a Patient With Eosinophilia-Myalgia Syndrome Associated With L-Tryptophan Ingestion Archives of Dermatology · 1990 · 11 citations
    3. Comparison of the Pathology of Fascia in Eosinophilic Myalgia Syndrome Patients and Idiopathic Eosinophilic Fasciitis Dermatology · 1993 · 11 citations
    4. Dermal Mucinosis in the Eosinophilia-Myalgia Syndrome Archives of Dermatology · 1990 · 8 citations
    5. Telogen effluvium associated with eosinophilia-myalgia syndrome Journal of The American Academy of Dermatology · 1991 · 5 citations
    6. The eosinophilia-myalgia syndrome Clinics in Dermatology · 1994 · 4 citations
    7. A patient with eosinophilia-myalgia syndrome. PubMed · 1990 · 1 citations
    8. Eosinophilic Fasciitis Associated With Tryptophan Ingestion Archives of dermatology · 1991 · 20 citations
    9. THERAPEUTIC CHALLENGES IN POLYAUTOIMMUNITY: ANIFROLUMAB FOR LUPUS ERYTHEMATODES IN OVERLAPPING AUTOIMMUNE SYNDROMES The Journal of Rheumatology · 2025
    10. MIXED CONNECTIVE TISSUE DISEASE EVOLVING FROM THE SEQUENTIAL OVERLAP OF SYSTEMIC LUPUS ERYTHEMATOSUS, SJÖGREN’S SYNDROME, RHEUMATOID ARTHRITIS AND DERMATOMYOSITIS: A FOLLOW-UP The Journal of Rheumatology · 2025
    11. Non‐infective mucocutaneous presentations of human immunodeficiency virus infection Australasian Journal of Dermatology · 1997 · 8 citations
    12. Dermatologic Manifestations of Human Immunodeficiency Virus Infection Mayo Clinic Proceedings · 1992 · 53 citations
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    15. Anticonvulsant-Induced Cutaneous Reactions CNS Drugs · 1999 · 18 citations
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    18. Tinea capitis in adult women masquerading as bacterial pyoderma Journal of the American Academy of Dermatology · 2003 · 32 citations
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    20. Acne Harper's Textbook of Pediatric Dermatology · 2011 · 2 citations
    21. Macrophage Activation Syndrome/Secondary Hemophagocytic Lymphohistiocytosis in Adult‐Onset Still's Disease: An Uncommon Initial Presentation in a Young Nepalese Female: A Case Report Clinical Case Reports · 2025
    22. Systemic-Onset Juvenile Idiopathic Arthritis with unusual Cutaneous Manifestation and peripheral eosinophilia: Case Report Authorea (Authorea) · 2023
    23. Clin-Alert Clin-Alert · 2002
    24. Skin manifestations associated with systemic diseases – Part I Anais Brasileiros de Dermatologia · 2021 · 11 citations
    25. Medical Dermatology Australasian Journal of Dermatology · 2024 · 2 citations
    26. Aldesleukin Elsevier eBooks · 2015
    27. Acne and acneiform eruptions Elsevier eBooks · 2011 · 2 citations
    28. Anthelminthic drugs Side effects of drugs annual · 1992
    29. Cytostatics and immunosuppressive drugs Side effects of drugs annual · 1989
    30. Dermatological Drugs, Topical Agents, and Cosmetics Side effects of drugs annual · 2015 · 1 citations