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research The experimental study of C57BL/6 mouse skin hair follicle development

January 2010 in “Chinese journal of clinical anatomy”

This study observed that hair follicle development in C57BL/6 mice begins at fetal stage E15.5, with a rapid increase in hair follicle numbers from E17.5 to three days after birth.

research The Stability of Vitamin A-induced Metaplasia of Mouse Vibrissa Follicles In Vitro

18 citations , October 1978 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that excess vitamin A induced stable glandular morphogenesis and mucous metaplasia in embryonic mouse vibrissa follicles, even after switching to standard medium.

research Nestin as a marker of unipotent epithelial progenitor cells differentiate into outer root sheath keratinocytes in embryonic and adult hair follicles

June 2022 in “Research Square (Research Square)”

This study revealed that nestin-expressing progenitor cells capable of becoming ORS keratinocytes are present during both hair follicle development and in adult hair follicles.

research Nestin as a marker of unipotent epithelial progenitor cell differentiation into outer root sheath keratinocytes in embryonic and adult hair follicles

May 2022 in “Research Square (Research Square)”

This study found that nestin-expressing unipotent progenitor cells capable of differentiating into outer root sheath keratinocytes are present during hair follicle development and in adult hair follicles.

research Impact of different mating and surgical protocols on the establishment of a mouse model for fetal scarless skin healing

September 2025 in “Biological Procedures Online”

This study presented a refined surgical protocol for a fetal mouse model that improves pregnancy success, reduces fetal loss, and allows for consistent phenotypic outcomes, enhancing research in scarless skin regeneration.

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community Why does this industry still revolve around 5-AR inhibitors?

40 upvotes 5 years ago

Hair loss treatments still rely heavily on minoxidil, finasteride, and RU58841, with little innovation. Future treatments like stem cell therapy and RNA technology show promise but are not yet available.

community Finasteride is a risk in pregnancy with unprotected sex

118 upvotes 6 years ago

Finasteride may pose a risk during pregnancy, so using a condom is recommended if a partner is pregnant. It is advised to stop finasteride before trying to conceive due to potential effects on fetal development.

community DHT is about to get smashed ….

802 upvotes 2 years ago

The conversation discusses hair loss treatments like topical finasteride with minoxidil, oral dutasteride, and essential oils. Oral treatments like dutasteride and finasteride are seen as more effective, though some prefer topicals to avoid side effects.

community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

in Technology 613 upvotes 4 months ago

A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

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