The Experimental Study of C57BL/6 Mouse Skin Hair Follicle Development

    January 2010 in “ Chinese journal of clinical anatomy ”
    Lin Zhang
    TLDR Hair follicles in C57BL/6 mice develop rapidly from late embryonic stages to shortly after birth, with key growth and regeneration phases identified.
    The study investigated the development of hair follicles in C57BL/6 mice at various life stages. It was found that hair follicle development began at embryonic day 15.5 (E15.5) and the number of hair follicles increased rapidly from E17.5 to 3 days after birth. By the 9th day after birth, most hair follicles reached the 8th stage of development. In adult mice, 95% of hair follicles entered the growth stage IV after depilation, with a significant portion entering the degradation period by day 22. This period of rapid hair follicle increase was suggested as a key phase for studying hair follicle regeneration mechanisms.
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