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GlossaryEctodermal Dysplasia

genetic disorders affecting skin, hair, nails, teeth, and sweat glands

Ectodermal Dysplasia (ED) refers to a group of genetic disorders that affect the development of the ectodermal layer, which is responsible for forming the skin, hair, nails, teeth, and sweat glands. Individuals with ED often experience symptoms such as sparse hair, missing or malformed teeth, and an inability to sweat properly, which can lead to overheating.

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research Specific Ectodermal Enhancers Control the Expression of Hoxc Genes in Developing Mammalian Integuments

June 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

The HoxC gene cluster and its enhancers are essential for developing hair and nails in mammals.

research Deletion of Hoxc13 in Frogs Reveals Key Steps in the Molecular Evolution of Cornified Skin Appendages

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Deleting the Hoxc13 gene in frogs shows its crucial role in developing skin structures similar to hair.

research Ectodermal Dysplasia: Otolaryngologic Manifestations and Management

37 citations, June 2002 in “The Laryngoscope”

Ectodermal dysplasia causes various symptoms and early treatment is important for eye, dental, and skin issues.

research A Direct Link Between Prss53, Hair Curvature, and Skeletal Dysplasia

February 2019 in “bioRxiv (Cold Spring Harbor Laboratory)”

The gene Prss53 affects hair shape and bone development in rabbits.

research The Disrupted Balance Between Hair Follicles and Sebaceous Glands in Hoxc13-Ablated Rabbits

18 citations, August 2018 in “The FASEB journal”

Rabbits lacking the Hoxc13 gene show similar hair and skin issues to humans with ECTD-9, making them good for research on this condition.

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community Verteporfin and Microneedling

in Treatments 5 months ago

Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.