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    GlossaryPremature Hair Loss (early hair loss)

    loss of hair occurring earlier than typically expected

    Premature hair loss, also known as early onset hair loss or premature balding, refers to the loss of hair that occurs at an earlier age than typically expected, often before the age of 30. This condition can be caused by a variety of factors including genetics, hormonal imbalances, stress, nutritional deficiencies, and certain medical conditions. It is characterized by thinning hair, receding hairlines, or bald patches, and can affect both men and women.

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      signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

      learn HMI-115

      much-hyped research compound targeting prolactin receptor in scalp

      learn Rapamycin

      mTOR regulator and immunosuppressant used more recently for anti-aging and hair regrowth

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      community Why do some people (specially those with diffuse balding) experience more regrowth just with DHT blockers?

      in Chat  40 upvotes 2 days ago
      Diffuse thinners often experience more hair regrowth with DHT blockers like finasteride, possibly due to less DHT sensitivity and the presence of miniaturized, not completely bald, follicles. However, regrowth varies widely among individuals, influenced by factors like genetics, the stage of hair loss, and treatment methods such as minoxidil, microneedling, and dermarolling.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Ketoconazole shampoo for early-stage shedding looks like working!

      in Ketoconazole  33 upvotes 1 month ago
      Ketoconazole shampoo may help with early-stage hair loss by stopping hair regression and promoting new hair growth, though its effectiveness as a DHT blocker is debated. Users report varying results, with some experiencing dryness and others seeing improvement when used 2-3 times a week.

      community Early Hair Loss - Starting Fin (19M)

      in Finasteride  6 upvotes 6 years ago
      A 19-year-old experiencing early hair loss started using finasteride to address diffuse thinning, despite concerns about potential side effects. They also use T/Gel and OGX Thick and Full shampoo, and have a dermatologist appointment scheduled to explore possible allergies.
      21M early hair loss — Fin only or Fin+Min? Anyone regret skipping minoxidil?

      community 21M early hair loss — Fin only or Fin+Min? Anyone regret skipping minoxidil?

      in General  167 upvotes 1 month ago
      A 21-year-old with early hair loss is considering starting finasteride, either orally or topically, and is unsure about adding minoxidil due to concerns about commitment and effectiveness. They plan to start with microdosing finasteride, possibly adding minoxidil later, and will also try microneedling, rosemary oil, castor oil, and ketoconazole shampoo.