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Glossary Bioavailability

proportion of a substance that enters the bloodstream and works

Bioavailability refers to the proportion of a drug or other substance that enters the bloodstream when introduced into the body and is thus able to have an active effect. For example, if you take a vitamin pill, bioavailability determines how much of that vitamin actually gets absorbed and used by your body, rather than being excreted. This concept is crucial in pharmacology and nutrition because it affects the efficacy of medications and supplements.

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Research

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research Nanospanlastic vesicles as novel strategies for enhancing anti-glaucoma drug bioavailability

January 2025 in “The Pharma Innovation”

This review discusses how nanospanlastics, a type of ultra deformable vesicular nanocarrier, could enhance glaucoma management by improving the delivery and effectiveness of intraocular pressure-lowering agents, tackling adherence challenges, and advancing targeted therapies, according to the authors.

research Advances of Non-Ionic Surfactant Vesicles (Niosomes) and Their Application in Drug Delivery

260 citations , January 2019 in “Pharmaceutics”

This study highlights that niosomes, or non-ionic surfactant based vesicles, offer an advantageous drug delivery system due to their stability, cost-effectiveness, and ability to enhance drug bioavailability and targeting efficiency for various therapeutic agents.

research Principles and clinical applications of transcutaneous laser-assisted drug delivery: A narrative review

6 citations , January 2024 in “Scars Burns & Healing”

This article reviews 12 clinical applications for transcutaneous laser-assisted drug delivery in skin disorders and concludes that it has potential for broader treatment use.

Preparation of Finasteride Capsules-Loaded Drug Nanoparticles: Formulation, Optimization, In Vitro, and Pharmacokinetic Evaluation

research Preparation of finasteride capsules-loaded drug nanoparticles: formulation, optimization, in vitro, and pharmacokinetic evaluation

28 citations , February 2016 in “International Journal of Nanomedicine”

This study found that freeze-dried finasteride nanoparticles improved the stability, solubility, and in vitro dissolution of the drug, indicating potential benefits for poorly water-soluble drugs.

research Mucoadhesive Polymer Hyaluronan as Biodegradable Cationic/Zwitterionic-Drug Delivery Vehicle

1 citations , January 2015 in “ADMET and DMPK”

This study observed that hyaluronan's transformation into HA·3Ca and its hydrate increases drug absorption by changing its molecular characteristics, influenced by zwitterionic character and acidic pH.

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Community Join

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community The homeless crackhead protocol

4487 upvotes 1 year ago

The conversation humorously suggests that drug use might be more effective for hair retention than traditional treatments like minoxidil or finasteride. It attributes full heads of hair in homeless individuals to lifestyle factors like reduced stress or hormonal changes.

community Haircafe: Are dutasteride tablets less effective than dutasteride gel capsules?

in Finasteride/Dutasteride 38 upvotes 1 year ago

Dutasteride tablets are less effective than softgel capsules because they require a fat-based environment for proper absorption. Softgel capsules, like Avodart, are designed to maximize bioavailability, while powdered tablets may result in significantly lower DHT suppression.

community My 200IQ genius master plan for dirt cheap dutasteride - can anyone see flaws to this plan?

11 upvotes 4 weeks ago

The conversation discusses a plan to test cheap generic Dutasteride capsules from India for authenticity using a UK drug testing service, WEDINOS, to identify reliable options for cost-effective hair loss treatment. Concerns are raised about the consistency and reliability of these generics, even if initial tests show they contain Dutasteride.

community Out of curiosity, why are Finasteride pills formulated as small tablets, while Dutasteride pills are much larger soft gel capsules?

in Finasteride/Dutasteride 41 upvotes 1 year ago

Finasteride and Dutasteride are used for hair loss, with Dutasteride often in gel form for better bioavailability. Switching from Finasteride to Dutasteride is common, with some users combining treatments like Minoxidil for improved results.

community Update:Switched from powdered dutasteride (DHT unchanged) to softgel (almost 80% reduction) test results

35 upvotes 1 week ago

Switching from powdered dutasteride to softgel significantly reduced DHT levels, suggesting softgels are more effective due to better bioavailability. Users discuss the ineffectiveness of compounded forms and emphasize the importance of proper formulation for absorption.

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