Search

for
Search:

Research

5 / 1000+ results

research Expression of MK6a dominant-negative and C-terminal mutant transgenes in mice has distinct phenotypic consequences in the epidermis and hair follicle

30 citations , October 1999 in “Differentiation”

This study found that expression of certain mutant keratin genes in mice led to severe alopecia, suggesting a similar mechanism could cause hair loss in humans.

research Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure.

252 citations , November 1995 in “The EMBO Journal”

Blocking EGFR in mice causes hair loss and skin changes.

Canonical and Dominant Negative Peroxisome Proliferator-Activated Receptor Gamma Isoforms Are Differentially Expressed in Human Skin and Skin Appendages

research 223 Canonical and Dominant Negative Peroxisome Proliferator-Activated Receptor γ Isoforms are Differentially Expressed in Human Skin and Skin Appendages

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that cPPARγ and dnPPARγ isoforms are differentially expressed in healthy human skin, suggesting that PPARγ modulators may have compartment-specific effects depending on isoform presence.

research APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex

199 citations , April 2010 in “Nature”

A gene called APCDD1, which controls hair growth, is found to be faulty in a type of hair loss called hereditary hypotrichosis simplex.

Activin Controls Skin Morphogenesis and Wound Repair Predominantly via Stromal Cells and in a Concentration-Dependent Manner via Keratinocytes

research Activin Controls Skin Morphogenesis and Wound Repair Predominantly via Stromal Cells and in a Concentration-Dependent Manner via Keratinocytes

81 citations , September 2005 in “The American journal of pathology”

This study found that activin affects both stromal cells and keratinocytes in skin morphogenesis and repair, with dose-dependent effects on keratinocytes demonstrated through transgenic mouse models.

View more "dominant-negative" in research →

Community Join

5 / 47 results

community Why some people experience problems on Finasteride/Dutasteride (my theory)

in Research/Science 18 upvotes 9 months ago

Some people have side effects from finasteride and dutasteride due to hormonal predisposition, especially if DHT dominant. Alternatives like RU58841, Pyrilutamide, and Breezula are suggested to target scalp androgen receptors without altering overall hormones.

community Do you believe these studies are real or just fear mongering

in Finasteride/Dutasteride 157 upvotes 11 months ago

Finasteride can regrow hair but may cause depression and suicidal thoughts in some users. The connection between finasteride and mental health issues is debated, with some attributing it to pre-existing conditions or stress.

community How is dht not beneficial to you?

in Finasteride/Dutasteride 111 upvotes 7 months ago

DHT is important for sexual function and mood, but finasteride and dutasteride can reduce DHT, causing side effects like reduced libido and erectile dysfunction. These treatments are effective for hair loss, but their impact on DHT leads to debate.

community High Estrogen causing hair loss?

16 upvotes 3 years ago

A 24-year-old male using topical finasteride for hair loss is experiencing thinning despite treatment and has high estrogen levels. He is seeking advice on whether high estrogen could be causing hair loss and how others with high estrogen levels have addressed it.

community 5 Months on topical Fin/Min progress: grows hair and boobs

in Progress Pictures 159 upvotes 11 months ago

The user experienced significant hair growth using topical finasteride and minoxidil but noticed nipple changes, suggesting early gynecomastia. They plan to stop the treatment and consider blood work to check hormonal balance.

View more "dominant-negative" in community →

Learn

— no results

Try a deeper search in learn →

Experts

— no results

Try a deeper search in experts →

Clinics

— no results

Try a deeper search in clinics →