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Did you mean DNA fragmentation?

Glossary DNA fragmentation

breaking of DNA strands into smaller pieces

DNA fragmentation refers to the breaking of DNA strands into smaller pieces. This can occur naturally during processes like apoptosis (programmed cell death) or can be induced by external factors such as radiation or certain chemicals. In a clinical or research setting, measuring DNA fragmentation can be important for understanding cell health, diagnosing diseases, or assessing the quality of sperm in fertility studies.

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Research

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research Faculty Opinions recommendation of Tracking research trends and hotspots in sperm DNA fragmentation testing for the evaluation of male infertility: a scientometric analysis.

January 2020 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

This review reports an increasing trend in sperm DNA fragmentation research over the past 20 years, with a focus on lifestyle, asthenozoospermia, and varicocele, and highlights the TUNEL technique as widely used.

research Tracking research trends and hotspots in sperm DNA fragmentation testing for the evaluation of male infertility: a scientometric analysis

48 citations , December 2019 in “Reproductive Biology and Endocrinology”

This review found an increasing trend in research on sperm DNA fragmentation over the past 20 years, especially focusing on lifestyle factors, asthenozoospermia, and varicocele, with the TUNEL technique as a predominant method.

research Finasteride-induced secondary infertility associated with sperm DNA damage

36 citations , February 2011 in “Fertility and Sterility”

This case report suggests that discontinuing low-dose finasteride in a 48-year-old man led to a significant reduction in sperm DNA fragmentation index, indicating a possible link between finasteride and sperm DNA damage.

research Apoptosis in human skin development: Morphogenesis, periderm, and stem cells

253 citations , March 1994 in “Developmental dynamics”

This study suggests that programmed cell death plays a crucial role in shaping the structure of the human epidermis and its appendages during development.

research Recent advances in understanding and managing male infertility

104 citations , May 2019 in “F1000Research”

This review discusses recent research on male infertility causes and treatments, emphasizing the need for further understanding of idiopathic sperm abnormalities and molecular factors to improve patient outcomes; it reports no new clinical results.

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community How many guys here experiencing sides from Fin also watch porn regularly?

22 upvotes 1 week ago

Some users attribute erectile dysfunction (ED) to finasteride, but others suggest porn use or other factors might contribute. There are mixed opinions on finasteride's side effects, with some experiencing mental health issues and others defending its use for hair loss.

community Should you stop finasteride if you're trying to conceive?

40 upvotes 1 month ago

Stopping finasteride 3 to 6 months before trying to conceive may improve sperm quality and increase chances of conception. Many users reported successful pregnancies after pausing finasteride, with some switching to topical finasteride and oral minoxidil during this period.

community IVF process on Finasteride and effects of stopping finasteride.

138 upvotes 9 months ago

Concerns about finasteride affecting sperm quality and embryo abnormalities during IVF. The user plans to stop finasteride for 6 months and use minoxidil, microneedling, a red light cap, and saw palmetto shampoo to manage hair loss.

community Long time Dutasteride users/experts please respond.

8 upvotes 3 weeks ago

Dutasteride and finasteride may affect sperm quality and fertility, with recommendations to stop use before trying to conceive. Dutasteride takes 4-6 months to clear from the system, while finasteride clears in about a week, but waiting longer is advised for optimal fertility.

community Haunting study is making me considering cycling fin/dut

in Research/Science 158 upvotes 1 year ago

Concerns about the long-term effects of dutasteride and finasteride on fertility, with discussions on cycling these medications to mitigate risks. The conversation highlights skepticism about study methodologies and the importance of weighing treatment risks against potential fertility issues.

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learn sh-Polypeptide-7

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