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GlossaryFranz diffusion cells

laboratory devices measuring substance diffusion through barriers

Franz diffusion cells are laboratory devices used to study the rate at which substances, such as drugs or cosmetic ingredients, pass through a barrier, typically skin or a synthetic membrane. They consist of two chambers separated by the barrier: one chamber holds the test substance, while the other contains a fluid that collects the diffused substance, allowing researchers to measure how quickly and effectively the substance penetrates the barrier.

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Influence of Application Time and Formulation Reapplication on the Delivery of Minoxidil through Hairless Mouse Skin as Measured in Franz Diffusion Cells

research Influence of Application Time and Formulation Reapplication on the Delivery of Minoxidil through Hairless Mouse Skin as Measured in Franz Diffusion Cells

5 citations, January 1994 in “Skin Pharmacology and Physiology”

Minoxidil absorption in skin is slowed by cleansing, depends on how long it stays on the skin, and is not much affected by reapplication.

research The In Vitro Use of the Hair Follicle Closure Technique to Study the Follicular and Percutaneous Permeation of Topically Applied Drugs

12 citations, March 2012 in “ATLA. Alternatives to laboratory animals”

Hair follicles significantly affect the skin absorption of some drugs.

research Heat Enhanced Follicular Delivery of Isotretinoin to the Skin

8 citations, June 2019 in “Pharmaceutical research”

Applying heat with certain chemicals can greatly improve how well isotretinoin gets into the skin through hair follicles.

research Nanostructured Lipid Carriers Loaded with 17-α-Estradiol Accumulate into Hair Follicles

January 2020 in “Journal of the Brazilian Chemical Society”

Tiny lipid particles loaded with a hormone gather in hair follicles, which may help treat hair loss.

research Transport of Niosomal Aminexil Through Whole Abdominal Skin of Rats

March 2018 in “International Pharmacy Acta”

New niosomal formulation effectively delivers aminexil through rat skin.

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community Peptides that Stop Hair Loss? | In-depth Literature Review Video

in Research/Science 74 upvotes 5 months ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community Sharing my 3.5 year journey, keep grinding guys

in Progress Pictures 228 upvotes 7 months ago

The user shared a 3.5-year hair loss treatment journey using 1 mg finasteride daily and minoxidil foam, noting significant improvement, especially in the third year. They also mentioned using Nizoral shampoo twice a week and supplements like vitamin D3, biotin, and omega 3 and 6.

community Interesting article links major MPB theories to western diet (and life-style)

in Research/Science 59 upvotes 1 month ago

Poor diet and lifestyle contribute to male pattern baldness. Treatments like Minoxidil, dietary changes, and lifestyle adjustments may help slow hair loss.

community Dutasteride takes 1-3 months to work in the scalp. Not weeks. Be careful.

in Finasteride/Dutasteride 41 upvotes 3 months ago

Dutasteride takes 1-3 months to affect scalp DHT levels, not just a week. The prostate absorbs Dutasteride faster than the scalp due to different vascular networks and enzyme densities.

community Topical Dutasteride. Does it work?

in Finasteride/Dutasteride 13 upvotes 6 months ago

Topical dutasteride may be effective for hair loss by staying in the scalp and minimizing bloodstream absorption, potentially improving hair results and reducing side effects. The user seeks advice on its effectiveness.

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