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research Grand challenges in dermatologic drug discovery: four priorities to transform skin disease treatment

January 2026 in “Frontiers in Drug Discovery”

This study highlights that while advances in dermatology, such as biologics and JAK inhibitors, have improved treatments for conditions like atopic dermatitis and psoriasis, challenges remain, including issues with lasting efficacy and the need for more personalized therapies.

research A Review on the Ethnomedicinal Plants Used in Zimbabwe for the Treatment and Management of Skin Conditions: Perspectives on Pharmacological and Toxicological Evaluation

August 2025 in “OBM Integrative and Complementary Medicine”

This review consolidates evidence on 93 plant species used in Zimbabwe for treating 21 skin-related conditions, reporting antimicrobial, anti-inflammatory, and antioxidant properties, though safety data remains inconsistent.

research Ancient-modern concordance in Ayurvedic plants: some examples.

139 citations , October 1999 in “Environmental Health Perspectives”

This article reviews the scientific exploration of Ayurvedic medicinal plants and discusses their modern applications, such as a drug developed from Commiphora wightti for lipid disorders, without reporting new clinical findings.

research Use of spironolactone in dermatology.

9 citations , April 2011 in “PubMed”

This review discusses spironolactone's dermatologic applications, particularly for conditions like hirsutism and female pattern hair loss, but reports no new results; it also highlights safety concerns in pregnancy and men.

research Montagna Symposium 2017—Precision Dermatology: Next Generation Prevention, Diagnosis, and Treatment

1 citations , May 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

This meeting synopsis on the 66th Annual Montagna Symposium reports no new results but outlines discussions on precision dermatology, integrating molecular insights with clinical applications for personalized skin care.

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Community Join

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community We should actually be hopeful for these recent new developments

112 upvotes 1 year ago

AI advancements, like AlphaFold, are speeding up drug discovery for hair loss, promising more effective treatments. Current options like minoxidil and finasteride have limitations, but new developments could improve solutions in 5-10 years.

community Wouldn’t it be funny if there already was a drug that existed which reactivated sleeping follicles? It would be our own version of Ozempic

202 upvotes 1 year ago

PP405 shows promise for reactivating hair follicles, with potential maintenance using 5AR inhibitors. Current treatments like Minoxidil and finasteride are effective but have limitations, and there is hope for more effective solutions in the future.

community Topical Metformin for Hair Transplant donor area skin/hair regeneration?

4 upvotes 1 year ago

Topical Metformin shows potential for regenerating hair follicles and minimizing scarring in hair transplant donor areas, similar to Verteporfin but without its side effects. The discussion suggests considering Metformin for post-hair transplant care, though more human trials are needed.

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

76 upvotes 2 years ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community 2 years fin only 1mg/daily + 4 months of gradually introducing Dut 0.5mg/daily

1706 upvotes 1 year ago

A user experienced significant hair regrowth using finasteride 1 mg daily for two years and gradually introduced dutasteride 0.5 mg daily over four months. They reported no side effects and plan to switch fully to dutasteride due to its cost-effectiveness and potential effectiveness.

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Learn

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learn TDM-105795

How is TDM-105795 used in hair-related products, and is it being explored as a topical treatment, an oral option, or both? TDM-105795 is not sold in any hair product — it is an unapproved experimental compound. The public trial registry shows it has been studied only as a topical scalp solution, in three completed company trials (the largest a 71-participant, 16-week Phase 2); no oral programme is registered, and no peer-reviewed publication exists.
How does TDM-105795 differ from more established hair loss ingredients when included in experimental or emerging treatments? TDM-105795 is an experimental topical drug described as a thyroid-receptor agonist, unlike minoxidil or finasteride. It has one 16-week Phase 2 trial in 71 men, with no statistical test or peer-reviewed results published and no head-to-head comparison.

learn Valproic acid

Anti-seizure and mood-stabilising drug

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