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GlossaryCytochrome P450

enzymes metabolize drugs and toxins in the liver

Cytochrome P450 (CYP) refers to a large family of enzymes that play a crucial role in the metabolism of various substances within the body, including drugs, toxins, and hormones. These enzymes are primarily found in the liver and are essential for the detoxification process, as well as the synthesis of cholesterol, steroids, and other lipids.

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Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1

research Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1

1 citations, May 2022 in “Frontiers in Pharmacology”

Astilbin can potentially calm overactive immune responses, like in Type 1 Diabetes, by suppressing certain cell activities and reducing inflammation.

research Response to Effectiveness of Dutasteride in a Large Series of Patients with Frontal Fibrosing Alopecia in Real Clinical Practice

2 citations, April 2021

The authors suggest that 5-α-reductase inhibitors, like dutasteride, are effective in treating frontal fibrosing alopecia and should be the first-line treatment, with other options for severe cases. They also recommend further research on Janus kinase inhibitors.

research Air Pollution, Autophagy, and Skin Aging: Impact of Particulate Matter on Human Dermal Fibroblasts

68 citations, September 2018 in “International Journal of Molecular Sciences”

Air pollution (PM10) increases skin inflammation and aging by reducing collagen and may trigger a repair response in skin cells.

Genotyping Of The Rs1800440 Polymorphism In CYP1B1 Gene And The Rs9258883 Polymorphism In HLA-B Gene In A Spanish Cohort Of 223 Patients With Frontal Fibrosing Alopecia

research Genotyping Of The Rs1800440 Polymorphism In CYP1B1 Gene And The Rs9258883 Polymorphism In HLA-B Gene In A Spanish Cohort Of 223 Patients With Frontal Fibrosing Alopecia

1 citations, September 2023 in “Acta dermato-venereologica”

Certain genetic variants are linked to frontal fibrosing alopecia in Spanish patients.

research Mind the Gender Gap: Does Prolactin Exert Gender and Site-Specific Effects on the Human Hair Follicle?

36 citations, November 2009 in “Journal of Investigative Dermatology”

Prolactin may affect hair growth differently based on gender and scalp area.

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community How does finasteride leave your body?

in Chat 13 upvotes 7 months ago

Finasteride is metabolized in the liver and excreted through urine and feces. Users humorously discuss its excretion, with one joking about it being expelled through ejaculation.

community here is why isotretinoin might cause hair loss and maybe why dupa happens.

in Research/Science 7 upvotes 1 year ago

Isotretinoin may cause hair loss by increasing DHT through a precursor androgen, DHEAS. Treatments like topical antiandrogens (RU58841, pyrilutamide) and drugs increasing PPAR-y expression (pioglitazone) might prevent this hair loss.

community Should I apply my grapefruit topically instead of injecting it into my bloodstream?

in Satire 74 upvotes 1 year ago

The conversation is a satirical discussion about using grapefruit for hair regrowth, with suggestions ranging from injecting it to applying it topically or anally. Some users claim unusual benefits like emitting a green aura or jumping high.

community Fin/Dut and Metabolism Speeds…

in Finasteride/Dutasteride 8 upvotes 2 months ago

A user speculates that a fast metabolism might affect the effectiveness of dutasteride for hair loss. Another user argues that drug response is unrelated to metabolism speed.

community RU-58841 Lung Disease Possibility | Chest pain, "heart issues", etc

in Treatment 23 upvotes 8 months ago

Some users of RU-58841 report cardiovascular symptoms like heart palpitations and chest tightness, which may be linked to its metabolites causing lung disease. The safety of RU-58841 is uncertain due to lack of long-term data and concerns about product purity, especially from gray market sources.

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