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research The in vitro Assembly of Hair Follicle Keratins: Comparison of Cortex and Companion Layer Keratins

13 citations , January 2002 in “Biological chemistry”

This study found that hair follicle-specific keratins can form different structural assemblies depending on ionic conditions, with hair cortex keratins requiring physiological salt conditions to form intermediate filaments.

A Discrete Transition Zone Between Cuticle and Cortex Layers of a Human Hair Fiber: Changes Observed in the Presence of Breast Cancer

research A discrete transition zone between cuticle and cortex layers of a human hair fibre: changes observed in the presence of breast cancer

1 citations , October 2017 in “ecancermedicalscience”

This study observed that the molecular structure of keratins in hair fibres' discrete transition zone differs in breast cancer patients, with altered lipid ester absorption bands reverting post-cancer removal.

research Activation of the Notch pathway in the hair cortex leads to aberrant differentiation of the adjacent hair-shaft layers

109 citations , June 2000 in “Development”

This study reports that activating Notch signaling in the hair follicle cortex of transgenic mice caused abnormal differentiation of the medulla and cuticle, highlighting potential cell-cell interactions.

research Probing neuronal functions with precise and targeted laser ablation in the living cortex

2 citations , September 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study demonstrated that ablation of individual somatostatin-expressing interneurons increased activity in nearby neurons of the mouse motor cortex during motor learning.

research Investigations on the penetration of hydrolyzed wheat proteins into human hair by confocal laser-scanning fluorescence microscopy

11 citations , January 2000 in “Journal of cosmetic science”

This study found that hydrolyzed wheat proteins extensively penetrated both untreated and chemically treated hair, primarily occupying areas like the endocuticle and cortex.

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community I’ve been on oral finasteride/Proscar for 15 years. (AMA)

in Treatment 11 upvotes 2 years ago

A user has been on oral Finasteride/Proscar for 15 years and started using topical Minoxidil, RU58841, and Dutasteride, along with microneedling, 2 years ago. They shared progress pictures and discussed their treatment routine.

community My Theory Of Androgenic Alopecia

16 upvotes 9 months ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

community 3,5 months of only topical minoxidil

776 upvotes 9 months ago

A 24-year-old reported new hair growth on temples after 3.5 months of using topical minoxidil without shedding. They plan to add finasteride to maintain progress, as minoxidil alone may not be enough long-term.

community Finasteride does deplete important nuero-active steroids

11 upvotes 3 years ago

Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

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