27 citations
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March 2008 in “Journal of The European Academy of Dermatology and Venereology”
Men with a certain type of hair loss (AGA) have higher bad cholesterol and lower good cholesterol levels, making them more likely to get heart disease.
1 citations
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January 2013 in “Advanced Biomedical Research”
This study suggests that greater sensitivity to androgens, as indicated by higher than grade 2 androgenic alopecia, may reduce the risk of schizophrenia by 8.62 times.
This meta-analysis reports that 5-alpha-reductase inhibitors are associated with a 31% increased risk of depression, with varying outcomes depending on the comparator group, highlighting significant heterogeneity across studies.
Results are not reported in this commentary, but it discusses the influence of different controlgroup choices—an active-comparator versus non-drug users—on measuring depression risk in studies of 5-alpha reductase inhibitors.
This study found that patients with frontal fibrosing alopecia had higher hair shaft concentrations of titanium, zinc, aluminum, and iron, possibly linked to the use of metal-containing products.
A humorous discussion on hair loss, suggesting girlfriend ASMR might counteract finasteride's effects, with a proposed experiment involving finasteride, ASMR, and controlgroups. Participants joke about evolutionary theories, ASMR, and the effects of DHT on balding.
Adding exosomes to a treatment of dutasteride and minoxidil for hair loss increased hair count by 55% at 6 months and 46% at 1 year compared to the controlgroup. The controlgroup did not receive exosomes or PRP.
SCUBE3, a protein linked to hair growth in moles, was discovered over 25 years ago and is being developed by Amplifica for potential hair loss treatment. Concerns exist about SCUBE3's association with cancer, as it is a protein that promotes cell growth, which could potentially trigger cancer development if used for hair growth therapy.
A group buy for hair loss treatments including Harmine 19a, TM5614, Abiraterone Acetate, and others. A compound, BMS-202, that can potentially reverse gray hair is also mentioned.
The user has been using a combination of treatments including Dutasteride, Minoxidil, RU58841, ketoconazole shampoo, microneedling, and low-level laser therapy to address hair loss but continues to experience shedding and density loss. Despite high testosterone and iron levels, the user is frustrated with the lack of improvement and is considering adjusting treatment or exploring other options like a hair transplant.
What’s the science behind Botox injections for androgenetic alopecia?Small published studies and a 2025 meta-analysis report hair-count gains from scalp botulinum toxin injections, but nearly all of them lack control groups, and reviewers of the same literature call the evidence low-quality; the treatment is off-label and not approved for hair loss anywhere.
Could cetirizine help control autoimmune triggers in alopecia areata?No published trial has tested cetirizine in alopecia areata; one registered trial has not reported results. Small trials in pattern hair loss report modest benefit, so any use for alopecia areata is off-label and unproven.
Does metformin help control DHT levels that trigger androgenic alopecia?Metformin has been shown to lower circulating androgens in women with PCOS, but no published study has measured scalp DHT, 5-alpha reductase activity in the follicle, or hair density in anyone taking it — so its effect on pattern hair loss is untested, and it is not a DHT blocker.