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Glossary Internal Standard

substance added to samples to ensure accurate measurements

An Internal Standard (IS) is a substance added in a constant amount to samples, calibrators, and quality controls in an analytical experiment. It is used to correct for variations in sample preparation and instrument response, ensuring more accurate and consistent results. This technique is particularly useful in fields like biochemistry and pharmacology, where precise quantification of compounds is critical.

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Research

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Quantitative Analysis of Finasteride Tablets Dissolution Content with Non-Isotopically Labeled Internal Standard by Paper Spray Ionization Mass Spectrometry

research Quantitative analysis of finasteride tablets dissolution content with non-isotopically labeled internal standard by paper spray ionization mass spectrometry

2 citations , September 2018 in “Journal of Separation Science”

This study demonstrated that using finasteride impurity as a non-isotopically labeled internal standard in paper spray ionization–mass spectrometry can effectively and efficiently measure finasteride tablet dissolution, achieving results comparable to high-performance liquid chromatography.

research The Platelet Rich Plasma (PRP) Preparation and Standardization of time interval for scalp hair loss

December 2022 in “Journal of Pakistan Association of Dermatologists”

In this study, PRP treatment for scalp hair restoration, combined with finasteride and minoxidil, resulted in reduced hair fall, stronger hair, and satisfactory regrowth in patients, with a satisfaction level of up to 90%.

research Targeted Determination of Residual Sex Hormones in Cosmetics Using Magnetic Solid-Phase Extraction with Isotope-Labeled Internal Standards by UHPLC-MS/MS

December 2025 in “Molecules”

This study developed a method using UHPLC-MS/MS and MSPE to detect trace amounts of sex hormones in cosmetics, finding progestins and estrogens in some products, and performed a preliminary safety evaluation for residual progesterone in hair loss prevention cosmetics.

research Matrix matching in quantitative bioanalysis by LC–MS/MS a dream or a reality?

2 citations , December 2019 in “Bioanalysis”

This article reviews analysis techniques in LC-MS/MS and discusses the potential use of a novel in-sample calibration curve method, but reports no new experimental results.

research Simultaneous determination of multi-class active pharmaceutical ingredients by UHPLC-HRMS

2 citations , May 2021 in “Journal of pharmaceutical and biomedical analysis”

This study utilized a UHPLC-HRMS method to identify eight active pharmaceutical ingredients, such as ketoconazole and minoxidil, in 26 out of 100 analyzed cosmetic products.

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Community Join

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community The Placebo Group Has It Worse Than The Standard Prescription 0.5mg Group. -The fear is all in your head.

190 upvotes 11 months ago

Dutasteride at 0.5mg may have fewer sexual side effects than expected, with many side effects attributed to psychological factors (nocebo effect). The placebo group experienced more side effects, suggesting fear and anxiety might contribute to perceived side effects.

community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

in Technology 613 upvotes 4 months ago

A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

community Scalp hydration's surprising link to hair growth cycle regulation

in Technology 23 upvotes 4 months ago

Scalp hydration may influence hair growth by affecting the signaling pathways that control the hair growth cycle. Users suggest using facial moisturizer, aloe vera, and oils for scalp hydration.

community Is there a consensus on RU these days? Pyril turned out to be a bust right?

in Research/Science 17 upvotes 2 years ago

The conversation discusses the effectiveness and safety of hair loss treatments, specifically RU58841 and Pyrilutimide (Pyril), with users sharing that Pyril was no more effective than a placebo and expressing concerns about the safety of RU58841 based on personal experiences and the lack of pharmaceutical interest.

community 22M , A year of progress on finesteride

39 upvotes 1 month ago

A 22-year-old male experienced progress with 0.5 mg daily finasteride for hair loss but noticed recent shedding, which may be a synchronized shed. Users suggest continuing the current dose, considering increasing to 1 mg, or exploring additional treatments like GHK-cu, while noting that watery semen is a common side effect.

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Learn

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learn Stem Cell Factor

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

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Experts

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Hair System Specialist
The Standard
Ouahigouya, Burkina Faso

Clinics

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