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Hair loss discussion includes potential HMI-115 treatment. Topical mucuna pruriens shows good results, blocking prolactin possibly more important than blocking DHT.

The potential of lowering prolactin levels to regrow hair, with a reference to Bayer's drug HMI 115 which has been indicated as having this effect. Treatments mentioned include Minoxidil and Finasteride, as well as RU58841.

The potential availability of a new hair loss treatment called HMI-115, which has shown promising results in experiments on monkeys but is not yet available to the public. Replies cautioned against using unproven substances from shady labs.

HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

A user who is trying alternative treatments, such as mucuna pruriens dissolved in water/alcohol and a blend of jojoba oil, rosemary oil, and peppermint oil, for hair loss. Other users have shared anecdotal evidence, discussed the potential effectiveness of certain treatments, and questioned the time sensitivity of experimenting with new treatments.

User suggests a DIY zix formula for hair loss treatment and shares personal success with it. Another user disagrees, calling zix a "snake oil potion" and advises finding a real treatment instead.

A user's experience with microneedling monotherapy and potential treatments such as finasteride, minoxidil, Stemoxydine, rosemary oil, peppermint oil, and RU58841 for reversing hair loss.

A user asks about the appropriate zinc dosage to offset side effects while taking 0.5 mg of finasteride daily. Responses suggest zinc has a minor effect on hormones compared to finasteride.

Topical aldactone is discussed for its effects on men's hair and muscles. The conversation explores its potential benefits and side effects compared to other treatments like Minoxidil, finasteride, and RU58841.

The conversation discusses using topical finasteride and minoxidil for hair loss, focusing on the crown and mid-scalp areas. The user is optimistic about seeing results in 3 to 6 months.

A user is making a homemade topical finasteride solution by dissolving crushed finasteride tablets in ethanol and PG. They are unsure if the final solution maintains the intended concentration after filtering and are considering adding more ethanol to ensure accuracy.

The user is considering making a homemade topical finasteride solution using an ethanol-based carrier. They are inquiring if a solution containing partially denatured ethyl alcohol and benzalkonium chloride is suitable.

Topical treatments like minoxidil and finasteride are preferred for hair loss due to ease of use and natural appearance. Hair systems are considered high-maintenance and less genuine.

Topical minoxidil and oral finasteride are effectively promoting hair growth with minimal side effects, such as no impact on sex drive. Users report positive results and reduced hair shedding, with some using a combination of topical foam containing both minoxidil and finasteride.

Topical finasteride is less popular due to inconvenience, cost, and availability, while oral finasteride is favored for ease and safety. Some users experience side effects with topical use, but find it effective with minoxidil, though opinions on its efficacy vary.

Minoxidil helped regrow hair from NW3 to NW2 in 5 months despite initial shedding, with additional use of Vitamin D3/K2 on the scalp. Users discuss patience during shedding and the importance of continuing treatments like Minoxidil and Finasteride.

Topical dutasteride may not significantly reduce hair loss and could potentially increase testosterone, leading to further hair loss. Users report side effects like mood changes, sleep issues, and severe side effects, with no significant progress in hair regrowth.

RU58841 is considered effective by some users, but finasteride and minoxidil are commonly used with varying dosages to manage side effects. Users report different experiences with treatments like pyrilutamide, fluridil, and RU58841, with some seeing results and others not.

The conversation discusses using topical exosomes with a derma roller for hair loss. Users also mention minoxidil for treatment.

After 8 months of using topical finasteride, hair miniaturization continues, raising concerns about its effectiveness. Microneedling is suggested as a possible complementary treatment.

Topical finasteride may reduce more scalp DHT but is seen as inconsistent and messy compared to oral finasteride. Users report mixed results with both forms, with some preferring oral for its convenience and consistent dosing, while others find topical effective but harder to apply.

Applying Minoxidil takes users between 10 seconds to 20 minutes, with most finding quicker methods more efficient. Techniques vary from using foam, liquid, or spray, with some users recommending buzz cuts for easier application.

Topical dutasteride, especially at higher concentrations, can be effective for hair loss when combined with microneedling to enhance absorption. Users discuss the side effects of finasteride and dutasteride, with some preferring topical treatments to avoid systemic side effects.

Topical finasteride and minoxidil, combined with microneedling, are recommended for treating thinning hair areas, with 1-2 sprays daily being effective and having fewer side effects than oral finasteride. Starting microneedling at 1.0mm is advised for effectiveness while minimizing invasiveness.

A user is seeking advice on making a topical bicalutamide solution as an alternative to RU58841 for hair loss, while already using dutasteride and minoxidil. They are considering crushing bicalutamide pills and adding them to their minoxidil.

Topical estrogen or estradiol for hair loss is being discussed for its effectiveness compared to finasteride. Users are sharing their experiences and opinions on its potential benefits.

The conversation discusses using minoxidil foam as a solvent for topical finasteride. Ingredients of minoxidil foam include butane, cetyl alcohol, glycerin, and purified water.

The conversation discusses the effectiveness and skepticism around topical dutasteride for hair loss, with mentions of combining it with other treatments like minoxidil and oral medications. Some users doubt its efficacy due to lack of independent studies and potential conflicts of interest.

Topical dutasteride is suggested as a low side-effect treatment for hair loss, with a proposed dose of 0.025% 1ml/day. It is considered better than finasteride due to its even inhibition of DHT isoforms and lower systemic absorption.

The user has been using finasteride for 6 months with decent results and recently added topical minoxidil. They are concerned that salicylic acid in their skincare products might reduce minoxidil's effectiveness.