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GlossaryTopical Antiandrogens

medications applied to skin to block androgen effects locally

Topical antiandrogens are medications applied directly to the skin to block the effects of androgens, which are hormones that can contribute to conditions like acne, hirsutism (excessive hair growth), and androgenetic alopecia (pattern hair loss). By inhibiting these hormones locally, these treatments can help manage symptoms without the systemic side effects associated with oral antiandrogens.

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Tracking 9 products like 97 RuDerma PG Free, 98 RuDerma, 99 Pyrilutamide solution, 278 Mane Regain - RU58841 5% Solution and 122 Regrowth Labs SP2 NO PG from by companies like MinoxidilMax, Amazon and Minoxidil Express. View all 9 products »

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community Topical Anti-Androgen users. What are y’all using currently? And what do you believe has the best chance of being approved? Or best results?

in Technology 13 upvotes 1 month ago

RU58841 is considered effective by some users, but finasteride and minoxidil are commonly used with varying dosages to manage side effects. Users report different experiences with treatments like pyrilutamide, fluridil, and RU58841, with some seeing results and others not.

community Topical anti-androgen availability in Australia

in Product 4 months ago

Availability of topical anti-androgens, especially RU58841, in Australia. Issues with customs seizures and lack of credible local sources.

community Is this hierarchy of topical anti androgens accurate?

in Ketoconazole 8 upvotes 2 years ago

User on fin, minox, and ketoconazole seeks to add another topical anti-androgen. Hierarchy of effectiveness: 1. RU55841, 2. Fluridil - Eucapil, 3. CB-03-01 - Breezula, 4. Ketoconazole; alfatradiol suggested as addition.

community How is there no topical anti-androgen that doesn’t go systematic?!

in Treatment 6 upvotes 4 years ago

Hair loss treatments discussed include Minoxidil, Finasteride, RU58841, Alfatradiol, and Eucapil. Topical treatments must penetrate skin and may go systemic, with effectiveness varying.

community Get excited: The topical anti-androgen that's going to change everything

16 upvotes 11 years ago

CB-03-01 is a topical anti-androgen with low absorption, offering potential as a side-effect-free alternative to Finasteride/Dutasteride for hair loss. It's in stage 2 clinical trials for acne and showing promise for male pattern baldness.

community to all people who cannot tolerate anti androgens (loe dose topical fin, pyrilutamide, CB) i am getting desperate, looking for a solution

in Research/Science 13 upvotes 1 year ago

The user tried Minoxidil without success, and Finasteride worked but caused sexual side effects even at a very low dose. They are seeking alternative treatments for hair loss as they cannot tolerate anti-androgens and are also in therapy for mental health.

community why has breezula been so dissapoiting, the new topical anti androgen that should replace finasteride?

in Finasteride/Dutasteride 6 upvotes 3 years ago

Breezula (clascoterone) initially performed better than finasteride for hair loss but then effectiveness decreased almost back to baseline after 6 months, raising questions about its strength.

community If RU58841 is such an effective anti androgen

in Research/Science 48 upvotes 10 months ago

RU58841 is discussed as a topical anti-androgen for hair loss, but its effectiveness and safety are not well-documented, leading to mixed opinions and experiences among users. Some combine it with finasteride, but concerns about side effects and lack of FDA approval limit its popularity.

community Protac degradation of the androgen receptor in mice shows good efficacy and no systemic drug could be found

in Research/Science 47 upvotes 1 year ago

The efficacy of degrading the androgen receptor through dermal application in DP cells, a delivery system for topical drugs that involves dissolving microneedles, and rosemary oil as an alternative anti-androgen.

community Another update. Almost a year on Dutasteride and Oral Minoxidil, after several years on finasteride and topical minoxidil. I’m fairly certain my hair is objectively worse than it was 5 months ago.

in Update 59 upvotes 1 year ago

A user's experience with hair loss treatments, including Dutasteride, Oral Minoxidil and Finasteride; potential side effects; and the potential of using anti-androgens or microneedling.

community Ru58841 and pyrilutamid receptor binding affinity vs spironolactone?

in Female 6 upvotes 1 year ago

Female considering adding topical anti-androgen, seeks advice on RU58841 or pyrilutamid's binding affinity compared to spironolactone.

community Starting Pyrilutamide tomorrow. Will keep everyone updated

in Research/Science 179 upvotes 2 years ago

The user healthydudenextdoor starting a new topical anti-androgen hair loss treatment, Pyrilutamide, and discussing their current regimen of finasteride and minoxidil.

community Are these all the anti androgen products?

in Treatment 6 upvotes 1 year ago

The conversation lists hair loss treatments including finasteride, dutasteride, RU58841, pyrilutamide, breezula, and fluridil, and suggests ketoconazole as another option. Some users warn against using certain treatments like cyproterone acetate, bicalutamide, and spironolactone due to their strong anti-androgen effects and potential impact on masculinity.

community Binding affinity does not equal potency for anti androgens? Comparing pyrilutimide to cb-03-01

in Research/Science 8 upvotes 2 years ago

Pyrilutimide and CB-03-01, two treatments for hair loss, have similar clinical trial results despite different binding affinities to androgen receptors. Factors other than binding affinity, like the time a drug stays bound to the receptor, may influence their effectiveness.

community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?

in Treatment 46 upvotes 6 months ago

The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.

community The New, Improved CB-03-01/Setipiprant Group Buy

27 upvotes 8 years ago

The group buy for CB-03-01, a topical anti-androgen for hair loss, was postponed and refunded due to issues with the product's form and solubility. The product, also known as Breezula, is an alternative to finasteride with fewer side effects, but its official release is delayed until 2021.

community Pyrilutamide and RU alternatives?

in Treatment 1 upvotes 1 month ago

Pyrilutamide is officially available for purchase, and users suggest Fluridil as an alternative topical anti-androgen. Some users report positive results with pyrilutamide from Koshine.

community How to Keep Your Hair on Steroids

in Treatment 16 upvotes 2 months ago

To minimize hair loss while using steroids, use finasteride or dutasteride and apply topical anti-androgens like RU58841. Avoid high doses of hair-toxic steroids; prefer testosterone, nandrolone, and boldenone.

community Testosterone is 1600, would taking low dose anti-androgens be a viable treatment option for people who’s T spikes on DHT-blockers?

in Treatment 46 upvotes 1 year ago

The post and conversation are about the user's high testosterone levels and their worsening hair loss despite trying various treatments. They are considering using low doses of anti-androgens to lower their testosterone levels as a potential solution.

community Last resort attempt. Studies suggest that finasteride topically actually inhibits up to 52% scalp dht which is smiles to dut 0.5mg daily. This solution contains: fin, min, melatonin and progesterone. Trial started today.

in Research/Science 9 upvotes 2 years ago

The conversation discusses a last-resort hair loss treatment combining topical finasteride, minoxidil, melatonin, and progesterone, with claims that topical finasteride can inhibit up to 52% of scalp DHT. One reply clarifies that progesterone is not an anti-androgen but has anti-androgenic properties because it competes with androgens for receptors.

community Are there ever going to be any oral DHT blocking treatments in the future?

in Product 6 upvotes 1 year ago

The discussion revolves around the need for future oral DHT blockers for hair loss treatment that don't have the side effects of current options like Finasteride and Dutasteride. One user suggests that the future of hair loss treatment will likely be topical anti-androgens, as they can target hair follicles without affecting the entire system.

community Serious question, is there nothing that can be done if Dutasteride doesn’t help to stop my hair loss?

in Finasteride/Dutasteride 61 upvotes 2 years ago

A 25 year old male who has been using finasteride and dutasteride for two years to treat his hair loss, with no success. Other treatments such as oral minoxidil, topical anti-androgens, RU58841, latanoprost, topical estrogen, CB 03 01, microneedling, keto 2% shampoo, vitamin D, Omega 3, B vitamins and probiotics were discussed.

community Dutasteride questions

in Finasteride/Dutasteride 6 upvotes 3 years ago

Switching to dutasteride as a hair loss prevention treatment, along with minoxidil, dermarolling and nizoral shampoo, and the potential benefits and side effects of using finasteride and/or dutasteride in combination with topical anti-androgens like RU58841.

community Low dose of fin 2x per week after stopping 1mg daily

in Finasteride/Dutasteride 1 upvotes 2 weeks ago

The user experienced side effects from daily finasteride and reduced the dosage to 0.25mg twice a week while continuing minoxidil. They are considering topical anti-androgens but are concerned about application difficulties and potential side effects.

community I don’t want to give up but running out of options

in Finasteride/Dutasteride 1 upvotes 4 months ago

The user has been on oral Dutasteride and Minoxidil for 16 months but continues to experience hair miniaturization. They previously used oral Finasteride and topical Minoxidil with success for 7 years and are now seeking advice on whether to switch back to topicals, adjust dosages, or consider other treatments like topical anti-androgens or Estradiol.

community DHT Itch is real. The connection between Acne and Male Pattern Baldness shows this

in Research/Science 64 upvotes 1 year ago

The conversation discusses the link between seborrheic dermatitis, acne, and male pattern baldness, suggesting that DHT may cause both skin conditions and hair loss. Treatments mentioned include RU58841, finasteride, dutasteride, minoxidil, Nizoral shampoo, and other topical anti-androgens.

community My Experience with Fin for Young Dudes Like Me

in Finasteride/Dutasteride 10 upvotes 3 years ago

A 19-year-old male shared his negative experience with finasteride, including side effects like vision issues, genital changes, pain, swollen lymph nodes, and mood alterations, which resolved after stopping the medication. He suggests alternative hair loss treatments like exercise, diet, possibly avoiding masturbation, topical anti-androgens, and dermarolling, emphasizing mental health over aesthetics.

community Insane MTF recovery 18 months blocking androgens

in Progress Pictures 145 upvotes 1 year ago

Hair loss recovery using estrogen and anti-androgen treatment for 18 months showed significant improvement. However, results vary and alternative treatments like RU58841 and Dutasteride may work without systemic feminization.

community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications

in Research/Science 92 upvotes 2 years ago

The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

in Research/Science 65 upvotes 1 year ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.