why has breezula been so dissapoiting, the new topical anti androgen that should replace finasteride?
    5/5/2021

    From the encyclopedia
    Clascoterone →

    a novel topical treatment that inhibits DHT on androgen receptors

    Finasteride →

    Frontline, gold standard treatment for combatting androgenic alopecia

    At a glance
    In this treatment experience post, the primary subjects mentioned are
    💧 Breezula (clascoterone) (topical) 7.5% BID 12 months
    the tone is 😞 negative with initial improvement then decline results.

    Other terms

    Breezula (clascoterone) initially performed better than finasteride for hair loss but then effectiveness decreased almost back to baseline after 6 months, raising questions about its strength.
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    5 / 5 results

      community Breezula is the final brick in the wall

       36 upvotes 2 months ago
      Breezula is discussed as a potential topical anti-androgen treatment for hair loss, with mixed opinions on its effectiveness and side effects compared to other treatments like finasteride, minoxidil, and RU58841. Some users express skepticism about its long-term efficacy and potential side effects, while others are hopeful for its approval and use in combination with existing treatments.

      community Why are people so negative regarding Clascoterone (Breezula)?

       20 upvotes 4 months ago
      Clascoterone (Breezula) shows promising hair growth results, but skepticism remains due to past disappointments with new treatments. It may be a good alternative for those who can't tolerate finasteride or dutasteride, and can potentially be combined with them and minoxidil for better results.

      community Clascoterone - Why are there so few posts if it’s already on the market?

      in Chat  34 upvotes 8 months ago
      Clascoterone is being discussed for hair loss, but its current acne formulation may not be suitable for scalp use due to potential skin irritation and lower dosage compared to Breezula. Users mention other treatments like finasteride, minoxidil, and pyrilutamide, with some expressing skepticism about clascoterone's effectiveness for hair loss.

      community Using 1% Clascoterone cream on hairline?

      in Chat  4 upvotes 5 months ago
      A 30-year-old man with hairline recession is considering using 1% Clascoterone cream on his hairline while awaiting a 5% Breezula product. He has been using oral Minoxidil for four years but stopped using Finasteride due to side effects.

      community Minoxidil alone, 4 months consistent usage

      in Is this regrowth?  525 upvotes 1 year ago
      Minoxidil 5% foam was used twice daily for 4 months, resulting in visible hair regrowth. Users discussed adding finasteride for better long-term results, with concerns about its side effects and alternatives like breezula and clascoterone.

    Related Research

    6 / 6 results
      Topical Antiandrogen Therapies for Androgenetic Alopecia and Acne Vulgaris

      research Topical Antiandrogen Therapies for Androgenetic Alopecia and Acne Vulgaris

      7 citations , December 2019 in “American Journal of Clinical Dermatology”
      This review discusses the potential efficacy of topical antiandrogen therapies for treating androgenetic alopecia and acne vulgaris, finding promising results but highlighting the need for more comprehensive studies.
      Antiandrogens and Androgen Inhibitors in Dermatologic Treatments

      research Antiandrogens and Androgen Inhibitors

      November 2020 in “Elsevier eBooks”
      This source outlines various antiandrogen and androgen inhibitor drugs used to treat cutaneous disorders of hyperandrogenism, detailing their mechanisms, uses, dosages, and side effects, with emphasis on spironolactone, finasteride, dutasteride, and oral contraceptives.
      New Drugs Under Investigation for the Treatment of Alopecias

      research New drugs under investigation for the treatment of alopecias

      26 citations , January 2019 in “Expert Opinion on Investigational Drugs”
      This review explored the new and emerging treatments for androgenetic alopecia and alopecia areata, finding that JAK inhibitors show promise for alopecia areata, while advancements in stem-cell research may eventually lead to new and improved treatments for androgenetic alopecia.
      New Therapeutics in the Management of Androgenetic Alopecia

      research Nouvelles thérapeutiques dans la prise en charge de l’alopécie androgénétique

      March 2025 in “HAL (Le Centre pour la Communication Scientifique Directe)”
      This thesis investigates the underlying mechanisms and treatment options for androgenetic alopecia, highlighting the molecular roles of androgens and genetic predispositions, and evaluates current and emerging therapies, such as PROTACs and Janus Kinase inhibitors, to enhance patient management.