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Glossary Phosphate Buffer

solution maintaining stable pH in biological experiments

A phosphate buffer, often referred to as phosphate-buffered saline (PBS), is a solution commonly used in biological research to maintain a stable pH environment. It consists of a mixture of sodium phosphate, sodium chloride, and sometimes potassium phosphate, which helps to mimic the ion concentration and osmolarity of the human body, making it ideal for experiments involving cells and tissues.

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community I want to prepare a Topical Catalase with Phosphate Buffered Saline Solution.

2 upvotes 5 months ago

The conversation discusses creating a topical catalase solution with phosphate buffered saline, glycerin, and polysorbate 20 for hair loss treatment. The user seeks advice on preparing this solution.

community mallia therapeutics 8T3 scd83 molecule for ffa/lpp mainly and aga

in Technology 9 upvotes 7 months ago

A user applied the 8T3 product for hair loss, targeting LPP and AGA, and plans to update on its effectiveness. The product uses a saline buffered phosphate vehicle, suitable for those intolerant to ethanolic vehicles.

community Creatine is the opposite of minoxidil !

324 upvotes 10 months ago

Creatine may counteract minoxidil's hair growth effects by closing potassium ATP channels, potentially leading to hair loss in predisposed individuals. Despite anecdotal reports, there is no conclusive evidence linking creatine to hair loss.

community P-1075: a BETTER version of Minoxidil

11 months ago

P-1075 is a more potent hair growth agent than Minoxidil, but it poses significant heart risks, making it unsafe for use. Despite promising results in macaques, concerns about its cardiotoxicity in rats have halted its development.

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

76 upvotes 2 years ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community Study on Sugar Intake on Male Pattern Hair Loss

19 upvotes 3 years ago

Excessive sugar and high-fat diets are linked to male pattern hair loss, with sweet beverages being a significant factor. Moderation in diet is advised, as diet alone may not fully prevent hair loss due to other factors like DHT sensitivity.

community What should I include in my blood test?

in Treatment 1 upvotes 10 months ago

The user has been using finasteride, dutasteride, and minoxidil without success and is considering a comprehensive blood test to explore other causes of hair loss. They are unsure about the necessity and cost of the extensive tests and are seeking advice on whether to proceed with the full panel or focus on specific tests.

community Blood work, is it worth to pay for it?

in Treatment 6 upvotes 10 months ago

The user is considering getting blood work to investigate the cause of ongoing hair loss despite using finasteride and dutasteride. Others suggest that while blood tests can provide useful health information, they may not change the hair treatment outcome.

community 21 y/o. MPB. Having an itchy/burning scalp no matter what I do or try. Any advice please? Thanks.

4 upvotes 6 years ago

A 21-year-old experiencing itchy and burning scalp with hair loss was diagnosed with MPB and scalp inflammation. They were prescribed Ketoconazole, Prednisone, Clindamycin, and Finasteride, and are considering trying antihistamines, dietary changes, and "nopoo" to alleviate symptoms.

community What are your thoughts on pre-finasteride blood work?

1 upvotes 3 years ago

The user is considering resuming finasteride after a 6-month break and is debating the necessity of extensive blood work, including hormone and health markers, to establish a baseline. They are unsure if the tests are necessary since they experienced no side effects previously.

community I (23M) want to stop my hair loss and I have a couple questions

3 upvotes 3 years ago

A 23-year-old male is experiencing aggressive hair loss and is considering using finasteride and minoxidil. He is seeking advice on whether to consult a dermatologist for seborrheic dermatitis, the necessity of various medical tests, and the cost of the treatment.

community Making your own RT1640 in China

4 years ago

RT1640, a combination of cyclosporin A, minoxidil, and RT175, is discussed as a potential treatment for hair regrowth and repigmentation. The unique formulation aims to enhance hair follicle growth and restore hair pigment without the negative side effects of immunosuppressants.

community Novel Formulation To Put An End To Hair Loss Once And For All.

in Research/Science 118 upvotes 10 months ago

A pharmacy student proposed a hair loss treatment using minoxidil, finasteride, clascoterone, and tretinoin, aiming for high effectiveness with minimal side effects. Reactions were mixed, with some questioning its feasibility and others showing interest.

community Accelerated Hair Loss from Creatine

137 upvotes 10 months ago

Creatine may cause hair loss in some individuals, especially those on finasteride, despite no scientific link. Personal experiences suggest individual sensitivity to DHT could be a factor.

community Why can’t we just do another creatine study?

153 upvotes 1 year ago

Creatine may worsen hair loss in some, especially with androgenic alopecia, but evidence is mixed. Some users experience no hair loss when using creatine with minoxidil and finasteride, while others notice increased shedding.

community is the reason why people are in denial about prolactin causing hair loss is the fact that prolactin is one of the hardest things to lower?

21 upvotes 2 years ago

High prolactin levels can cause hair loss, and finasteride may increase prolactin. Cabergoline or Vitamin B6 might lower prolactin, but combining them with finasteride requires caution.

community Results are in for my experiment with Creatine/Fin

129 upvotes 6 years ago

Creatine use with finasteride increased DHT levels, possibly affecting hair loss. The user plans to reduce creatine to stabilize DHT and hair shedding.

community 57% increased chance of pattern hair loss independently associated with the consumption of sugary beverages in men (p<0.001) Pt 2

484 upvotes 2 years ago

Sugary beverages increase the risk of pattern hair loss in men by 57%. Treatments discussed include Minoxidil, finasteride, and RU58841.

community Don't use PP405 from everychem. it is likely fake.

63 upvotes 1 year ago

PP405 from Everychem is likely fake and potentially harmful, with concerns about its stability and the risk of using the wrong MPC inhibitor, which could damage hair follicles. The real PP405 was studied under strict conditions, and DIY attempts are discouraged due to unknown formulation and quality control.

community Does anyone know the chemical formula for pelage pp405?

15 upvotes 1 year ago

The conversation discusses the lack of public information on the chemical structure of PP405, a hair loss treatment, and the challenges of synthesizing it without a patent. It also explores a patent related to hydrogen-based topical formulations for reducing oxidative stress and inflammation.

community Frènch Phàrmàcie gave me 10,000x the d0sage

1 year ago

A pharmacy error resulted in a finasteride solution being 100 times stronger than prescribed, not 10,000 times as initially feared. OP is advised to contact the pharmacy to clarify the preparation before traveling.

community The lowest cyproterone dose to stop mpb

4 upvotes 3 years ago

The conversation discusses using cyproterone acetate at 12.5 mg to manage hair loss, with concerns about its effects on testosterone and potential health issues. Other treatments mentioned include finasteride, dutasteride, minoxidil, and RU58841, with varying experiences and outcomes.

community Why doesn't phase 3 of PP405 start straight away?

in Chat 14 upvotes 8 months ago

Pelage is delaying the start of phase 3 trials for PP405 to 2026 due to necessary regulatory processes, despite having $120 million in funding. Users discuss the potential of PP405 for hair regrowth, with some expressing skepticism and others hopeful for new treatments like Breezula.

community PP405 (Everychem 3HP) Users - Assemble and share your story!

in Chat 19 upvotes 4 months ago

Users discussed the effectiveness of Everychem's solution, similar to PP405, with some reporting improved hair thickness and new growth. Concerns were raised about safety and the legitimacy of the product, with some users advising against purchasing research chemicals.

community Making PG free solution at home

1 upvotes 2 years ago

A user wants to make a solution for RU58841 and finasteride powder using only glycerin and asks if ethanol is necessary. They are seeking advice on whether glycerin alone is sufficient.

community Pelage Pharmaceutical Raises 120 million to continue PP405 Research. Link inside.

in Research/Science 73 upvotes 11 months ago

Pelage Pharmaceutical raised $120 million to continue research on PP405, a promising hair loss treatment that showed a 20% increase in hair density in 31% of men during a Phase 2a trial. The treatment was well-tolerated, with no systemic absorption, and Phase 3 trials are planned for 2026.

community PP405 (Everychem 3HP) users - assemble and share your updates!!

in Chat 44 upvotes 4 months ago

Users discussed experiences with Everychem's solution similar to PP405 for hair loss, noting some positive results like increased hair thickness and new growth. There was skepticism about the product's legitimacy and safety, with some users reporting early signs of effectiveness and others expressing concerns about the lack of evidence and safety profiles.

community PP405: The Ultimate Hair Loss Drug for Complete Hair Growth

211 upvotes 1 year ago

PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hair follicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.

community Is this real? Pp405-3hp @ everychem

4 upvotes 5 months ago

The conversation discusses the availability and legitimacy of a hair loss treatment called PP405-3HP. Users express skepticism about its release and reference patent information.

community Tretinoin buffering before minoxidil

7 upvotes 2 months ago

Buffering tretinoin with a moisturizer before applying minoxidil may help with itchy dandruff. Exfoliating the scalp with fingertips and using olive oil or conditioner can remove product buildup.