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GlossaryNeurosteroids

steroids produced in the brain that affect neuron function

Neurosteroids, also known as neuroactive steroids, are a class of steroids synthesized in the brain and nervous system. They play a crucial role in modulating neuronal activity, influencing mood, stress response, and cognitive functions by interacting with neurotransmitter receptors such as GABA and NMDA.

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community Proof that finasteride messes with neurosteroids

in Research/Science 230 upvotes 4 months ago

Finasteride can impact neurosteroids, potentially causing depression and other side effects in some users. Despite these concerns, many continue using it for hair loss, with some switching to topical applications to mitigate side effects.

community What is the real impact of dutasteride on neurosteroids? A little review of 2 scientific datas

in Research/Science 21 upvotes 4 months ago

Dutasteride at 0.5 mg/day does not significantly alter allopregnanolone levels, but higher doses (2.5 mg/day) do. Dutasteride may also have anti-neuroinflammatory effects, but the impact on neurosteroids is still debated.

community A systematic bro-science review of DHT, 5AR, neurosteroids, sexual health and 5AR inhibitors

in Research/Science 37 upvotes 2 years ago

Hair loss treatments, specifically 5AR inhibitors, can impact neurosteroids and sexual health. The effects of topical fin/dut on tissue-specific DHT levels are unclear.

community Insomnia and Finasteride

in Finasteride/Dutasteride 7 upvotes 3 years ago

A user reports experiencing insomnia as a side effect of taking finasteride for hair loss, which takes 1 to 2 hours to fall asleep and results in only about 5 hours of sleep per night. They suspect the cause is related to the downregulation of neurosteroids due to finasteride.

community Anyone here holding out for Breezula?

in Treatment 6 upvotes 4 years ago

The conversation is about individuals considering waiting for Breezula to treat hair loss instead of using Finasteride due to concerns about side effects. Some are opting for Finasteride now, while others are wary of its impact on neurosteroids.

community Progressive insomnia (treatment-resistant) due to Finasteride

in Finasteride/Dutasteride 7 upvotes 2 years ago

A medical student experienced hair loss slowing with Finasteride but developed severe, treatment-resistant insomnia. They tried various medications with little effect, suspecting Post-Finasteride Syndrome, and others suggested the insomnia might be linked to Finasteride's impact on neurosteroids.

community Hair Loss Associated with Escitalopram (anti-depressant). Do SSRIs Affect the Hair Follicle?

in Research/Science 7 upvotes 5 months ago

A 22-year-old male experienced hair loss potentially linked to escitalopram, which stopped after switching to vortioxetine. His depressive symptoms improved with continued treatment.

community People who tolerate dut better than fin?

in Finasteride/Dutasteride 32 upvotes 1 month ago

Dutasteride may have fewer side effects than finasteride, with some users experiencing better hair maintenance. Experiences vary, with some preferring dutasteride for fewer side effects, while others see no significant hair improvement.

community Finasteride affects both 5a reductase and 5b reductase

7 upvotes 5 years ago

Finasteride not only inactivates the 5a reductase enzyme but also affects the 5b reductase enzyme in a dose-dependent manner, which can impact sexual behavior and brain activity. The user experienced significant hair regrowth and side effects on 1mg of finasteride, which diminished after reducing the dose to 0.5mg, leading to no side effects and further hair improvement.

community The Battle of Norwood (2024) | Dut 0.5 mg ED + Oral Min 5 mg ED

in Progress Pictures 505 upvotes 5 days ago

community My kid secretly took my avodart what should i do

in Is this regrowth? 42 upvotes 1 month ago

A child accidentally took Avodart, leading to concerns about DHT suppression and its effects. Users humorously discuss potential consequences and treatments like DHT injections and topical solutions.

community Finasteride and Its Effects on Cognition: Where's the Science?

in Research/Science 29 upvotes 4 years ago

The user shared their experience with hair loss treatments, including low-dose minoxidil, finasteride, and essential oils, and expressed concerns about the cognitive side effects of finasteride. They are seeking more information on how finasteride may affect cognition and are considering whether to continue or stop the treatment.

community The safest way to use finasteride - my research

in Finasteride 23 upvotes 7 years ago

The post discusses microdosing finasteride to minimize side effects while treating hair loss. The user also mentions using minoxidil, biotin, and ketoconazole.

community Everyone is ignoring that plasma finasteride levels are 100x lower with topical compared to oral.

in Research/Science 127 upvotes 4 months ago

Topical finasteride results in plasma levels 100 times lower than oral finasteride, potentially reducing systemic side effects. Users report similar efficacy with fewer side effects, suggesting a preference for topical application.

community Oral or topical finasteride? .

in Chat 12 upvotes 3 months ago

A user is deciding between oral and topical finasteride for hair loss, noting oral finasteride's ease of use but broader effects. Another user simply recommends oral finasteride.

community The Bad Ending: You Lose Finasteride

in Satire 129 upvotes 3 months ago

The conversation humorously discusses the effects of stopping finasteride for two years, with users joking about hair loss and embracing baldness. Treatments mentioned include finasteride.

community Tired of playing this game on hard mode? (not click bait).

in Treatment 6 months ago

Hair loss can be linked to low testosterone, affecting DHT and estrogen levels. Treatments discussed include increasing testosterone, using Finasteride, and applying estrogen cream.

community Sulforaphane Topical to Degrade DHT - For People Who Want to Try the Theory that Explains Everything

in Treatment 38 upvotes 3 years ago

A user suggests making a potent sulforaphane topical to degrade DHT and promote hair growth. Another user notes that sulforaphane's low molecular weight might also lower systemic DHT.

community ecklonia cava?

in Question 4 upvotes 5 years ago

The conversation discusses using ecklonia cava as a natural alternative to finasteride for hair loss. Users share their experiences and opinions on its effectiveness.

community 4600 - result 9 month - Dr. Carman

in Progress Pictures 255 upvotes 9 months ago

A user shared their 9-month post-hair transplant results with 4600 grafts, using only Nourkin hair vitamins, Vitamin D, and B12, and expressed satisfaction. The replies debated the necessity of medications like finasteride and minoxidil for maintaining hair health.

community Allopregnanolone deficiency by 5-ari inhibition (fin/dut users)

in Finasteride/Dutasteride 11 upvotes 11 months ago

The conversation is about managing allopregnanolone deficiency caused by 5-alpha-reductase inhibitors like finasteride or dutasteride. Specific treatments discussed for hair loss include Minoxidil, finasteride, and RU58841.

community What else can I do to compliment Minoxidil?

in Update 4 upvotes 1 year ago

A user has been using minoxidil for hair loss and has seen positive results, but is seeking additional treatments to enhance its effects. One suggestion given is to use finasteride alongside minoxidil.

community 7 months oral fin 1 mg once daily, 3 months min 5% once daily same length, same angle, same lighting

in Progress Pictures 306 upvotes 1 year ago

The post and conversation are about a user's progress in treating hair loss using oral finasteride and topical minoxidil. The user expresses regret for not starting treatment earlier.

community PCOS female who posted before; saw Endo today. prescribed spironolactone and minox 5%

in Update 1 upvotes 1 year ago

PCOS female visited doctor for hair loss concerns, prescribed spironolactone and minox 5%. Doctor advised against finasteride or dutasteride, user considering self-medication with dutasteride.

community where does the renewed spironolactone hype come from?

in Research/Science 7 upvotes 1 year ago

Topical spironolactone is gaining attention as an alternative hair loss treatment, but it's not as effective as other options like finasteride. Oral spironolactone can cause side effects in men, and there are better topical alternatives like RU, Pyril, and CB.

community 1.5 years of Fin, switch 3 months ago to Dut, with 5 moths of Min too

in Progress Pictures 104 upvotes 2 years ago

User switched from Fin to Dut for better hair loss results, using 0.5mg Dut and 1ml Min daily. Some discuss potential side effects and benefits of Dut compared to Fin.

community Earliest we can get legitimate pyrilutamide

in Research/Science 46 upvotes 2 years ago

Pyrilutamide, a drug in phase 3 trials in China, potentially becoming available in late 2023 or early 2024; Finasteride being used as a current treatment for hair loss; and the possibility of joining a group buy for black market versions of Pyrilutamide.

community Would there be ANY reason to still take 5AR inhibitors if pyrilutamide does what is intended?

in Research/Science 17 upvotes 2 years ago

A potential new treatment for hair loss, Pyrilutamide, and the discussion of whether or not people should still be taking traditional treatments like Minoxidil and Finasteride with it.

community Best supplements to take while on fin to avoid sides?

in Finasteride/Dutasteride 25 upvotes 4 years ago

The conversation discusses using zinc and iron supplements to mitigate side effects of finasteride. It also mentions that shedding is a normal part of the process and suggests a healthy diet, exercise, and sleep to support hair health.

community Breezula CB-03-01

in Treatment 11 upvotes 4 years ago

The conversation is about a potential new hair loss treatment called Breezula CB-03-01. Users are discussing updates on its development and sharing personal experiences with making or using it.