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Glossary Genetic Mutations

changes in DNA sequence that can affect traits or health

Genetic mutations are changes in the DNA sequence of an organism's genome. These alterations can occur naturally during DNA replication or be induced by environmental factors such as radiation or chemicals. While some mutations are harmless or even beneficial, others can lead to diseases or disorders, including various forms of alopecia.

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community [Research Breakdown] The Genetic Edge: Unpacking Dutasteride vs Finasteride Potency

6 upvotes 3 weeks ago

Dutasteride is more effective than finasteride for increasing hair count, but finasteride is considered safer for long-term use unless hair loss is very aggressive. Starting with finasteride is recommended due to its effectiveness and safety profile.

community CRISPR Is Curing People Right Now. Genetic Hair Loss is Next?

112 upvotes 1 year ago

CRISPR shows promise for treating hair loss by targeting specific genes. Current treatments include Minoxidil and finasteride, but CRISPR could offer a more precise solution, though it is still expensive and in early stages.

community How a follicle next to it is so genetically different that it never miniaturized??

in Chat 219 upvotes 11 months ago

Genetic differences in hair follicles affect hair loss patterns. Treatments discussed include finasteride, dutasteride, minoxidil, and RU58841.

community DHT Isn’t the Only Factor in Hair Loss and That Might Be the Key to a Real Cure

373 upvotes 6 months ago

Hair loss involves more than just DHT, with genetic factors like TRPS affecting hair follicles. Treatments such as Amplifica's AMP-601 and AMP-303 target stem cells for potential hair growth solutions.

community If DHT is the cause of hair loss why do so many still lose hair on dutasteride?

in Finasteride/Dutasteride 9 upvotes 3 weeks ago

Hair loss can persist despite using treatments like finasteride, dutasteride, and minoxidil due to factors like genetic sensitivity, incomplete DHT blockage, and other hormonal influences. Individual responses vary, and some may require a combination of treatments to stabilize hair loss.

community The meds work: my dad at 23 yo vs me at 35 yo

1791 upvotes 1 year ago

Finasteride and oral minoxidil effectively maintain a youthful appearance and full head of hair, despite genetic predispositions to balding. The discussion also considers the impact of DHT blockers on masculinity and aging, with lifestyle choices like sunscreen use and a vegetarian diet mentioned.

community If we can clone a sheep why we can't cure baldness till now

in Research/Science 181 upvotes 11 months ago

Hair loss treatments like Minoxidil, finasteride, and stem cell therapies exist, but a complete cure is hindered by genetic complexity and market dynamics. Cloning hair follicles is considered a potential solution, but it's currently not feasible.

community Being Safe on Oral Minoxidil: tl;dr on the literature.

51 upvotes 1 year ago

Oral minoxidil is effective for hair loss but can cause cardiovascular side effects, such as pericardial effusion, especially in those with genetic predispositions. Starting with low doses and monitoring cardiovascular health are advised to reduce risks.

community Genuine question about VDPHL01's long term safety that I haven't seen discussed here

in Research/Science 28 upvotes 4 months ago

Concerns about the long-term safety of VDPHL01, an extended-release minoxidil, due to potential risks similar to Cantu syndrome, were raised, highlighting the lack of monitoring for chronic connective tissue changes. The conversation suggests that while the treatment may improve hair growth, it could lead to issues not detected in short-term trials.

community PRP treatment and Minoxidil: 5 months progress

in Progress Pictures 15 upvotes 1 year ago

The user experienced hair regrowth after 5 months using Minoxidil and PRP treatment. They also took various supplements and adjusted their diet to address deficiencies and support hair health.

community Why do we get bald from evolutionary perspective

in Chat 213 upvotes 1 year ago

Baldness is not an evolutionary disadvantage because it occurs after reproductive age. Treatments like Minoxidil and Finasteride are used for androgenetic alopecia but don't address the root cause.

community IVF process on Finasteride and effects of stopping finasteride.

138 upvotes 9 months ago

Concerns about finasteride affecting sperm quality and embryo abnormalities during IVF. The user plans to stop finasteride for 6 months and use minoxidil, microneedling, a red light cap, and saw palmetto shampoo to manage hair loss.

community Has anybody heard of this new cure?

2735 upvotes 8 months ago

A new hair loss treatment shows promise in mice but is unproven in humans. Effective treatments include finasteride and minoxidil.

community REVOLUTION in AUGUST: New possibilities according to Dr. Muñoz (pinacidil, cromakalim, diazoxide and nicorandil)

13 upvotes 1 year ago

Dr. Muñoz's discovery suggests that targeting potassium channels in fibroblasts could reactivate hair growth, offering new treatment possibilities for alopecia. Potential strategies include using minoxidil, diazoxide, and other potassium channel openers, as well as bioelectric devices and direct growth factor applications.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 1 year ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

community Iron supplement worked better than Minoxidil. Check your ferritin, even "normal" is low

67 upvotes 11 months ago

Iron supplementation may be more effective than Minoxidil for hair loss. Checking ferritin levels is important, as both low and high levels can affect health.

community So many horror stories about switching from fin to dut

in Finasteride/Dutasteride 58 upvotes 6 months ago

Switching from finasteride to dutasteride can cause initial shedding, but many see long-term hair regrowth and stabilization. Responses vary, with some experiencing fewer side effects and others finding it less effective.

community PSA: Caffeine and Hair Transplants

31 upvotes 2 years ago

A user shared their experience with a hair transplant, emphasizing the importance of avoiding caffeine 7 days before the procedure. Ignoring this advice led to reduced effectiveness of the numbing agent, causing significant discomfort during the transplant.

community Is anyone taking creatine while on fin and/or dut?

in Finasteride/Dutasteride 33 upvotes 2 years ago

The conversation discusses the use of creatine while on finasteride and/or dutasteride for hair loss. Opinions vary, with some users reporting no issues and others experiencing accelerated hair loss, suggesting effects are individual.

community Potential ( but not yet confirmed ) pp405 leak through korean media.

233 upvotes 10 months ago

A peptide-based hair loss treatment, PP405, reportedly increased hair density by 62% in 90 days, but these claims are unverified and met with skepticism. Users compared PP405 to Minoxidil and Finasteride, expressing doubts about its effectiveness without more evidence.

community DHT is making fun of you, let's not suffer!

17 upvotes 11 months ago

DHT negatively affects scalp hair while promoting body hair growth, causing frustration due to the lack of permanent solutions for baldness. Users discuss treatments like finasteride and potential future solutions like CRISPR technology.

community When you start balding you notice how unnatural this phenomenon is

532 upvotes 1 year ago

Hair loss is a common issue, with treatments like finasteride and minoxidil used but not as permanent cures. Frustration exists over societal perceptions and the lack of a definitive solution.

community Solving Hair Loss with Research at MIT

in Research/Science 595 upvotes 1 year ago

Hair loss treatments like minoxidil, finasteride, TDM-105795, and PP405. MIT is hosting a hackathon to find innovative hair loss solutions.

community Rosemary out here changing lives for the better

in Treatment 90 upvotes 2 years ago

Rosemary oil is being used as an addition to minoxidil and finasteride for hair health, with mixed opinions on its effectiveness. Some users report positive results, while others see no benefit or experience adverse effects.

community A Theory on Why Microneedling Works

175 upvotes 6 years ago

Microneedling may enhance hair regrowth by transferring stem cells to dormant follicles, improving the effects of minoxidil. Users discuss using microneedling with needle lengths around 1.5mm to stimulate hair growth.

community We need to keep these snake oil companies accountable.

in Treatment 120 upvotes 2 years ago

Biotin is being misleadingly marketed as a primary treatment for androgenic alopecia, overshadowing more effective treatments like finasteride and minoxidil. There is a call for increased awareness and accountability to prevent misinformation.

community Prolactin the Cause of Hair Loss? ABS-201 the Cure?

29 upvotes 2 months ago

Prolactin may contribute to hair loss, but targeting its receptor won't cure androgenetic alopecia. ABS-201 could be a useful alternative or adjuvant therapy, similar to JAK inhibitors, but not more effective than HMI-115.

community You should start with finasteride only

259 upvotes 1 year ago

Begin with finasteride to evaluate its effectiveness before adding minoxidil. Combining treatments may enhance results but could also increase side effects; individual responses differ.

community My estrogen levels are obscene

6 upvotes 1 year ago

A 30-year-old male using finasteride for hair loss has high testosterone and estrogen levels but no side effects. He is advised to monitor hormone levels, consider dietary changes, and use additional treatments like vitamin D3, minoxidil, and dutasteride for hair growth.

community FINASTRIDE and switch to DUTASTRIDE, my experience

in Progress Pictures 145 upvotes 2 years ago

The user shared their experience with Finasteride and Dutasteride for hair loss. They initially had success with Finasteride but switched to Dutasteride after experiencing shedding, which continued, and are now considering a hair transplant.