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GlossaryAntiandrogenic Activity

inhibits effects of male sex hormones like testosterone

Antiandrogenic activity refers to the ability of certain substances to inhibit the effects of androgens, which are male sex hormones like testosterone. This activity is important in treating conditions like androgenic alopecia (male-pattern baldness) and prostate cancer, as it helps reduce the influence of these hormones on hair follicles and prostate cells.

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community The story of RU58841/ PSK3841

Typical-Promise-3001 in Research 622 upvotes 5 months ago

RU58841, a potential hair loss treatment, was not commercialized due to marketability issues and lack of long-term safety data. Concerns about its formulation and delivery methods further complicate its use.

community 5 months on Spiro and 6 weeks on oral Monoxidil. Beyond thrilled with the results so far

dogbedblanket in Female 190 upvotes 4 years ago

Treatments for hair loss, specifically the use of Spironolactone (Spiro) and oral Minoxidil, as well as Finasteride and RU58841.

community Ru, Stemoxydine or Alfatradiol? What has your experience been with any of these 3?

RChopaa in Treatment 3 upvotes 1 year ago

The user is seeking advice on which treatment to add to their current regimen for male pattern baldness. They have previously tried Dutasteride, Nizoral, and oral Minoxidil, but experienced continued hair loss. They are specifically asking for experiences with RU58841, Stemoxydine, or Alfatradiol.

community Methods Of Staying Safe On Ru58841 - My 2 Cents

Prestigious-Name512 in Research/Science 12 upvotes 3 weeks ago

RU58841 is used topically to prevent hair loss by blocking DHT, with suggestions to drink grapefruit juice, take breaks, avoid microneedling, and use lower concentrations to reduce side effects. Users discuss applying it at night to minimize systemic absorption.

community Sweet Lord my DHT itch is finally gone

FWLIDC in Chat 49 upvotes 1 year ago

Hair loss itch stopped by adding RU58841 to treatment. Topical Finasteride and Pyrilutamide also mentioned as potential itch solutions.

community Everyone seems to be looking for an antiandrogen as an add on. But what about Estradiol & its derivatives ( excluding the low concentraion alfatradiool ) being used. Anyone has an experience with this ? Anything that won't cause feminization in the process ?

Cinderace1 in Chat 6 upvotes 4 months ago

The conversation discusses using estradiol and its derivatives for hair loss without causing feminization. Users mention alternatives like alfatradiol, topical 17b-Estradiol, and DIM (Diindolylmethane).

community A hair model who does beauty ads and has 3 million followers claims he went from almost a Norwood 3 to a perfect hairline in 8 months on only Minoxidil and Rosemary oil. Curious, what are people’s thoughts?

ThrowRA1212121211212 in Chat 1 year ago

This conversation discusses the results of a model who claims he went from almost a Norwood 3 to a perfect hairline in 8 months using only Minoxidil and Rosemary oil. The replies suggest that this could be realistic but long-term results would require additional treatments like finasteride or other medications to prevent further hair loss.

community I am having Success with RU58841 and 1mm Derma Roller

Deandestruct in Microneedling 19 upvotes 3 years ago

A user reported success with RU58841 and a 1mm derma roller for hair regrowth, noting significant improvement in hair density and reduced scalp visibility. They also mentioned using minoxidil and black castor oil in the past, with mixed results.

community Would Fluridil and Alfatradiol work effectively in conjunction with each other?

DoubleAmbassador in Treatment 7 upvotes 4 years ago

Whether using both Fluridil and Alfatradiol together could be more effective than either one alone as a hair loss treatment, given their different mechanisms of action.

community Dutasteride: More Than a DHT Reducer – A Potential Androgen Receptor Inhibitor?

Ok-Grapefruit-8563 in Finasteride/Dutasteride 31 upvotes 1 month ago

Dutasteride may inhibit androgen receptors in addition to reducing DHT, potentially explaining its effectiveness over finasteride for hair loss. Concerns about its impact on muscle growth are debated, with some suggesting no significant effects.

community Topical spironolactone - anti androgen

rhguven in Research/Science 9 upvotes 2 years ago

User asks about topical spironolactone experience. Two studies show it as promising anti-androgen treatment, with 5% cream available on Minoxidilmax website.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

Busy-Order-9093 in Chat 237 upvotes 3 months ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

community Can someone explain why it's "dumb" to just drink topical liquid minoxidil?

kyarew in Minoxidil 27 upvotes 1 year ago

The conversation discusses the risks and methods of ingesting liquid minoxidil for hair loss. Concerns include dosing accuracy, safety of ingredients, and potential side effects compared to using oral minoxidil tablets.

Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

MagicBold in Research 413 upvotes 2 months ago

Treating androgenic alopecia with minoxidil, finasteride, and antiandrogens, alongside exercise, cryotherapy, and natural substances to stimulate cold receptors for better hair growth. The method focuses on enhancing treatment effectiveness by considering environmental and behavioral factors and the role of cold receptors and muscle stress.

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens.

MagicBold in Research/Science 2 upvotes 2 months ago

A method for treating androgenic alopecia using minoxidil, antiandrogens, exercise, and cold exposure to promote hair growth. Environmental factors and lifestyle changes, like diet and exercise, can improve treatment effectiveness.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

MagicBold in Research 823 upvotes 3 months ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Why haven’t we seen anything about this

alexmurray55555 in Research/Science 19 upvotes 4 years ago

A double blind, placebo-controlled study that looked into the potential effectiveness of topical fluridil for treating male androgenetic alopecia, showing increased anagen to telogen ratios with no reported side effects on libido or sexual performance.

community New Study - Flavonoids More Effective Than Finasteride?

DowntownShorten in Research/Science 148 upvotes 1 year ago

A recent publication suggests that the flavonoids eriocitrin and silymarin may be more effective than finasteride in binding to the enzyme responsible for hair loss. People in the conversation are skeptical about the effectiveness and safety of these flavonoids until tested on humans, and some discuss their personal experiences with other treatments.

community Start taking care of your skin and hair loss TODAY! I was telling myself I didn’t care, but I think the difference in my facial expression says it all. Take action asap before more permanent damage is done. I hope I can inspire some of you, because it’s so worth it. Not for others, for yourself! <3

infinite_phi in Progress Pictures 583 upvotes 3 years ago

User shared progress in treating hair loss and improving skin, using treatments like finasteride, minoxidil, RU58841, tretinoin, microneedling, and skin care regimen. Others commented on the impressive results and asked about costs and side effects.

community List of natural supplements I have tried which did not slow my MPB

ts_andres in Chat 32 upvotes 9 months ago

A user shared a list of natural supplements they tried that did not stop their male pattern baldness (MPB), including vitamin D, biotin, and various oils. The conversation includes skepticism and jokes about one of the methods, injecting jellyfish mucus into testicles, and mixed opinions on the effectiveness of natural treatments.

community Have you guys heard about topical melatonin?

Dispiteous in Research 10 upvotes 5 years ago

Topical melatonin may improve hair density and thickness, and reduce hair loss and seborrhea with no significant side effects. The user made their own melatonin solution for hair treatment.

community Anyone wanna try and interview the developers of RU?

Lysander1999 in Research/Science 84 upvotes 3 years ago

The conversation discusses arranging an interview with the developers of RU58841 to clarify its safety and reasons for halted research, with some users expressing concerns about potential risks and others citing financial reasons for the discontinuation of studies. Specific treatments mentioned include RU58841, minoxidil, and finasteride.

community Shopping receipts are anti-androgenic?

Orangelightning77 in Chat 29 upvotes 6 months ago

The conversation discusses the potential use of thermal paper receipts, which contain estrogen, as a treatment for hair loss. Participants humorously debate its effectiveness compared to established treatments like Minoxidil and finasteride.

community Clotrimazole a better anti-androgen than Ketoconazole?

PulseQ8 in Research/Science 1 upvotes 4 years ago

Clotrimazole may inhibit testosterone better than Ketoconazole. The user considers applying Clotrimazole cream on the scalp for hair loss.

community Have you ever seen a "back from the dead" result that DIDNT use microneedling?

cretinouswords in Microneedling 33 upvotes 3 months ago

Some users report significant hair regrowth without microneedling, using treatments like finasteride, minoxidil, and dutasteride. Others believe microneedling enhances results, but opinions vary on its necessity.

community Pyrilutamide - your experience?

throwaway93047 in Product 12 upvotes 2 years ago

The conversation is about the lack of improvement in hair loss after using Pyrilutamide for 14 weeks, with the original poster unable to use Finasteride due to depression. Replies suggest that Pyrilutamide, like RU58841, may not work for everyone, and a more potent drug is being developed by Kintor.

community DHT levels after 4 weeks of Fina and 8 weeks of Fina + 4 weeks of Duta

keqq in Update 35 upvotes 5 years ago

The user reported early stage diffuse hair thinning and increased DHT levels after 4 weeks on Finasteride and 8 weeks on Finasteride plus 4 weeks on Dutasteride, despite the medications being authentic and stored properly. They are considering increasing their Dutasteride dosage due to the lack of side effects and are unsure if the treatment is helping their hair.

community 6 months progress no fin 27m topical foam minox

Spyro345345 in Progress Pictures 250 upvotes 1 year ago

The user has been using 5% Minoxidil foam twice daily, microneedling every two weeks, and Nizoral 2% shampoo weekly for hair loss treatment. They've seen improvements in their hairline and eyelashes, and are considering adding finasteride to their regimen.

community Obviously, all of us who are serious take antiandrogens and growth stimulants - what else are you doing lifestyle wise, dietary wise, and regiment wise to maximize your results?

SolaceInDysmporhia in Treatment 21 upvotes 7 months ago

The user follows a hair loss treatment routine including Propecia, oral minoxidil, ketoconazole, and plans to switch to dutasteride. They also focus on lifestyle changes, dietary supplements, and are considering laser therapy.

community Physio-metabolic method (antiandrogen, minoxidil, leg training and cold)

MagicBold in Treatments 309 upvotes 8 months ago

The method combines finasteride, minoxidil, intense leg exercises, and cold exposure to treat androgenetic alopecia. It aims to boost metabolism and reduce androgenic effects, enhancing hair growth.