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Did you mean 3α-Androstanediol?

Glossary3α-Androstanediol

metabolite of DHT involved in hair follicle regulation

3α-Androstanediol, also known as 3α-diol, is a metabolite of dihydrotestosterone (DHT), a potent androgen hormone. It plays a role in the regulation of androgenic activity in tissues, including the skin and hair follicles. Elevated levels of DHT are often associated with conditions like androgenic alopecia (male pattern baldness), making 3α-Androstanediol relevant in studies of hair loss and related treatments.

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community Sulforaphane Topical to Degrade DHT - For People Who Want to Try the Theory that Explains Everything

in Treatment 38 upvotes 3 years ago

A user suggests making a potent sulforaphane topical to degrade DHT and promote hair growth. Another user notes that sulforaphane's low molecular weight might also lower systemic DHT.

community Bile Acid-Mediated DHT Dysregulation Hypothesis

in Research/Science 13 upvotes 2 weeks ago

Elevated bile acids can inhibit the enzyme AKR1C2, leading to increased DHT levels, which may accelerate hair loss in those predisposed to androgenetic alopecia. Treatments mentioned include topical minoxidil and finasteride.

community Switched from finasteride to dutasteride - 2 month update

in Finasteride/Dutasteride 6 upvotes 1 year ago

The user switched from finasteride to dutasteride for hair loss treatment, but experienced increased libido, itchy scalp, and accelerated hair loss. Another user suggested that genetic variations might cause dutasteride to be less effective and recommended checking for specific genetic markers.

community What else can I do to compliment Minoxidil?

in Update 4 upvotes 1 year ago

A user has been using minoxidil for hair loss and has seen positive results, but is seeking additional treatments to enhance its effects. One suggestion given is to use finasteride alongside minoxidil.

community When someone posts a scalp tension theory

in Satire 267 upvotes 3 years ago

Hair loss theories discussed include poor blood flow, scalp tension, inflammation, and DHT. Treatments mentioned are massaging scalp, minoxidil, finasteride, and RU58841.

community How I started reversing Male Pattern Baldness naturally ?

in Question 6 upvotes 7 years ago

The user reversed male pattern baldness using a pro-thyroid diet, lifestyle changes, and scalp stimulation exercises, without Minoxidil or Finasteride. They reported reduced dandruff, itchiness, oiliness, and experienced hair regrowth and thickening over 15 months.

community Why is everyone not directly advised Dutasteride?

in Finasteride/Dutasteride 165 upvotes 1 month ago

Dutasteride is less commonly prescribed for hair loss because it is not FDA-approved for this purpose, unlike finasteride, which is more accessible and preferred due to fewer side effects. Dutasteride may be more effective in reducing DHT but has a longer half-life and potentially more significant side effects.

community "but it will hurt my gains bro"

in Satire 1302 upvotes 2 months ago

The conversation humorously discusses hair loss treatments like Minoxidil, Finasteride, and Dutasteride, and their effects on hair and muscle gains. Users debate effectiveness and side effects, mixing scientific approaches with jokes.

community Why is there so many people claiming Dutasteride destroyed their hair?

in Chat 25 upvotes 6 months ago

Some people claim Dutasteride worsened their hair loss, causing concern among users. Reasons suggested include initial shedding phases, incorrect attribution to Dutasteride when other factors are involved, genetic variations affecting drug response, and the possibility of non-authentic medication.

community Finasteride vs Dutasteride: The Science

in Research/Science 168 upvotes 10 months ago

The conversation compares Finasteride and Dutasteride for hair loss treatment, discussing their effectiveness and side effects. Users share personal results and consider combining treatments like Dutasteride with RU58841.

community Insane dutasteride shed 4 months after switching.

in Finasteride/Dutasteride 115 upvotes 1 year ago

The post and conversation are about a user's experience with hair loss treatments, specifically switching from finasteride to dutasteride. The user experienced significant hair shedding after the switch, with others suggesting patience, noting similar experiences, or questioning the user's decision and medical consultation.

community Testosterone and DHT levels through the roof yet has better hair than the majority of guys who are “healthy” genetics are everything

in Satire 554 upvotes 1 year ago

The conclusion of this conversation about hair loss is that genetics play a significant role in determining hair loss, and specific treatments like finasteride may not be effective against certain compounds like masteron and trenbolone.

community Why is Kevin Mann (Haircafe) Hated?

in Chat 62 upvotes 1 year ago

Hair loss treatments, including microneedling, minoxidil, finasteride and RU58841; the efficacy of these treatments; criticisms of Kevin Mann's content related to his selective data presentation and biases towards certain treatments; and other topics such as DHT being labeled a "trash hormone" and critiques of other hairloss YouTubers.

community PSA: Most men who stay on Fin will see the sexual side effects go away. Stop the fear mongering

in Finasteride/Dutasteride 191 upvotes 2 years ago

Finasteride can cause sexual side effects in less than 2% of men, but these often disappear over time, even if the treatment continues. Some users report persistent side effects, while others experience no issues or only temporary ones.

community Would there be ANY reason to still take 5AR inhibitors if pyrilutamide does what is intended?

in Research/Science 17 upvotes 2 years ago

A potential new treatment for hair loss, Pyrilutamide, and the discussion of whether or not people should still be taking traditional treatments like Minoxidil and Finasteride with it.

community Kintor’s KX-826 Pyrilutamide!!

in Research/Science 149 upvotes 3 years ago

KX-826 hair loss treatment completed trials with mild side effects. GT20029 may be ultimate cure, destroying androgen receptors causing baldness.

community The theory that explains everything - First Evidence of Hair regrow attributed to upregulating 3aHSD

in Treatment 174 upvotes 3 years ago

Hair regrowth treatment involving 3aHSD enzyme shows 6% improvement in 18 weeks. Sulforaphane, L-Menthol, and Dexpanthenol are potential ingredients for new hair loss solution.

community Debunk the debunk ? - Not sure but this study still exists ...

in Research/Science 24 upvotes 3 years ago

The conversation discusses hair loss treatments, specifically mentioning Minoxidil, finasteride, and RU58841. It highlights a study suggesting that sulforaphane may reduce DHT levels and promote hair growth in mice.

community The theory that explains everything. Please help me make this big!

in Research/Science 2453 upvotes 3 years ago

The post and conversation are about the role of the enzyme 3alpha-hydroxysteroid reductase in hair loss and the potential of compounds like procyanidin B2 and sulforaphane to boost its activity for hair regrowth. Further research is needed to develop effective treatments based on this theory.

community DHT levels after 4 weeks of Fina and 8 weeks of Fina + 4 weeks of Duta

in Update 36 upvotes 5 years ago

The user reported early stage diffuse hair thinning and increased DHT levels after 4 weeks on Finasteride and 8 weeks on Finasteride plus 4 weeks on Dutasteride, despite the medications being authentic and stored properly. They are considering increasing their Dutasteride dosage due to the lack of side effects and are unsure if the treatment is helping their hair.

community Trying to understand finasteride side effects and post finasteride syndrome

in Finasteride/Dutasteride 74 upvotes 4 years ago

The conversation discusses the side effects of finasteride, including low libido and erectile dysfunction, and the possibility of these effects being permanent, known as post-finasteride syndrome (PFS). Some users report personal experiences with PFS and debate whether the condition is real, with varying opinions on the reversibility of side effects and the role of individual biology.

community 3α-Hydroxysteroid dehydrogenase community driven study, not anytime soon guys.

in Research/Science 105 upvotes 3 years ago

High cost of studying 3α-Hydroxysteroid dehydrogenase in hair loss led to suggestions of crowdfunding for research. Users discussed using Procyanidin B2/melatonin topical treatment and tracking funds with blockchain.

community Is it me or are people losing their hair very young now?

in Finasteride/Dutasteride 143 upvotes 4 years ago

People notice more young individuals experiencing hair loss and discuss possible reasons, such as diet, hormones, and stress. Some treatments mentioned include finasteride, dutasteride, and minoxidil.

community fin + oral/topical minox + folexin + nizoral/head & shoulders + vitamin d. it works

in Update 33 upvotes 3 years ago

Finasteride is key for hair regrowth, supported by oral/topical minoxidil, Folexin, Nizoral/Head & Shoulders, and vitamin D. No side effects experienced; early intervention and patience are crucial.

community Proof that finasteride messes with neurosteroids

in Research/Science 230 upvotes 4 months ago

Finasteride can impact neurosteroids, potentially causing depression and other side effects in some users. Despite these concerns, many continue using it for hair loss, with some switching to topical applications to mitigate side effects.

community blood DHT levels shot up after doubling dutasteride dosage

in Finasteride/Dutasteride 20 upvotes 6 months ago

A user increased their dutasteride dosage from 0.5mg to 1mg daily, resulting in a rise in DHT levels from 148 pg/mL to 281 pg/mL, and is considering switching back to finasteride due to continued hair loss. Replies suggest retesting and emphasize the importance of bloodwork before starting treatments.

community I have a hard time believing that creatine overpowers fin/dut

in Finasteride/Dutasteride 109 upvotes 1 year ago

The conversation is about whether creatine causes hair loss in individuals who are taking finasteride or dutasteride for hair loss. Some users report experiencing hair loss when taking creatine, while others do not. There is no consensus on the issue.

community So what’s really the deal with dutasteride hairline ruining claims?

in Finasteride/Dutasteride 72 upvotes 2 years ago

The potential effects of dutasteride on hair loss, with some users reporting it improved their hairline while others experienced worsened hair loss or shedding. Other treatments discussed include minoxidil and finasteride, as well as RU58841.

community My Testosterone results before and after Finasteride

in Update 146 upvotes 3 years ago

Finasteride significantly increased testosterone levels for the user, with no major side effects except watery semen, which was resolved with zinc supplements. The user's hairline stopped receding and slightly improved.

community [25, F] [RANT] Shedding since March 2020. This just isn’t fair.

in Female 42 upvotes 3 years ago

User "missbloombastic" has been experiencing hair loss since 2016 and tried min, fin, multivitamins, and spiro with mixed results. Another user shares their struggle with hair loss and its impact on self-esteem, while a third user suggests checking blood tests and confirming the cause of hair loss.