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Glossary Collagenase

enzyme that degrades collagen in tissues

Collagenase is an enzyme that breaks down collagen, a key structural protein in the skin, bones, and connective tissues. This enzyme is crucial in processes like wound healing and tissue remodeling, as it helps to remove damaged collagen and make way for new tissue formation.

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Research

5 / 1000+ results

research Collagenase IV plays an important role in regulating hair cycle by inducing VEGF, IGF-1, and TGF-β expression

27 citations , September 2015 in “Drug Design Development and Therapy”

This study suggests that type IV collagenases, MMP-2 and MMP-9, play important roles in the hair cycle by regulating the expression of VEGF, IGF-1, and TGF-β in mice.

research Collagenase IV plays an important role in regulating hair cycle by inducing VEGF, IGF-1, and TGF-β expression.

26 citations , January 2015 in “PubMed”

This study found that the type IV collagenases, MMP-2 and MMP-9, play significant roles in the hair cycle, potentially through their influence on VEGF, IGF-1, and TGF-β expression.

Effects of Polygoni Multiflori Radix on Elastase and Collagenase Activities and Procollagen Synthesis in Hs68 Human Fibroblasts

research Effects of Polygoni Multiflori Radix on the Elastase, and Collagenase Activities and the Procollagen Synthesis in Hs68 Human Fibroblasts

2 citations , January 2014 in “The Korea Journal of Herbology”

This study found that Polygoni Multiflori Radix (PMR) reduced collagenase and elastase activity after UVB damage in fibroblasts, suggesting potential anti-aging properties for cosmetic use.

research A randomized pilot study to compare hair follicle cell suspensions prepared using trypsin alone versus trypsin in combination with collagenase type I for transplantation in vitiligo

5 citations , July 2019 in “Clinical and experimental dermatology”

This study found that incorporating collagenase type I into a noncultured hair follicle cell suspension technique improved cell yield and enhanced repigmentation in patients with stable vitiligo compared to dermabrasion alone.

research Localization of Type I Human Skin Collagenase in Developing Embryonic and Fetal Skin

22 citations , June 1994 in “Journal of Investigative Dermatology”

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Community Join

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community My Idea for a possible new hairloss treatment

53 upvotes 6 years ago

Exploring a potential hair loss treatment using the enzyme AKR1C2 to locally reduce DHT levels. Challenges include enzyme delivery through the skin and high production costs, with gene therapy or stem cells suggested as future alternatives.

community Comprehensive Microneedling Guide

292 upvotes 4 years ago

Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

community Calecim (PTT-6) Advanced Hair System with Topical Exosomes and Growth Factors for Hair Growth

1 year ago

Calecim (PTT-6) Advanced Hair System is a 6-week hair restoration product using stem cell-derived ingredients to stimulate hair growth. Users are skeptical, calling it overpriced and ineffective, suggesting alternatives like LLLT devices or PRP treatments.

community 21M - 8 months on oral minoxidil, crown still thinning. Considering fin - thoughts?

in Finasteride/Dutasteride 9 upvotes 5 months ago

The conversation suggests starting finasteride or dutasteride alongside minoxidil for better hair loss treatment, as minoxidil alone is seen as ineffective without a DHT blocker. Some users also mention considering RU58841 as an alternative to finasteride.

community A less common type of hairloss case

5 upvotes 5 months ago

High-dose Lysine and Histidine supplements caused curly/kinky hair and shedding due to Elastin dysfunction. Minoxidil, white tea, and dark grape juice were mentioned as treatments to inhibit Elastase and mimic Lysyl Oxidase.

Learn

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learn nonspecific group of soluble collagens

learn collagen

learn Hydrolyzed Collagen

learn hydrolyzed fish collagen

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