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Glossary Cochlea

spiral-shaped, fluid-filled inner ear structure converting sound to signals

The cochlea is a spiral-shaped, fluid-filled structure in the inner ear that plays a crucial role in hearing. It converts sound vibrations into electrical signals that are transmitted to the brain via the auditory nerve, allowing us to perceive sound.

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Research

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research EGFR signaling is required for regenerative proliferation in the cochlea: Conservation in birds and mammals

53 citations , January 2012 in “Developmental Biology”

EGFR signaling is essential for ear cell regeneration in both birds and mammals.

research Follistatin promotes LIN28B-mediated supporting cell reprogramming and hair cell regeneration in the murine cochlea

16 citations , February 2022 in “Science Advances”

This study found that coactivating LIN28B and follistatin enhances cochlear supporting cells' ability to regenerate hair cells in neonatal mice by reprogramming them into progenitor-like cells.

research Rapamycin but not acarbose decreases age-related loss of outer hair cells in the mouse Cochlea

15 citations , September 2018 in “Hearing research”

This study suggests that rapamycin, but not acarbose, can delay age-related loss of cochlear outer hair cells in UM-HET3 mice at doses that increase life span.