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    Glossary Chronic Inflammation

    long-term immune response causing tissue damage and disease

    Chronic inflammation, also known as persistent inflammation, is a prolonged and often harmful immune response that can last for months or even years. Unlike acute inflammation, which is a short-term response to injury or infection, chronic inflammation can result from ongoing exposure to irritants, autoimmune disorders, or unresolved acute inflammation. This persistent state can lead to tissue damage and is associated with various diseases, including arthritis, cardiovascular disease, and certain types of alopecia.

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    1. Macrophage Related Chronic Inflammation in Non-Healing Wounds Frontiers in Immunology · 2021 · 228 citations
    2. Long Ya Cao (Agrimonia pilosa Ledeb.) extract and its bioactive constituent (agrimonolide) attenuate chronic inflammation and accelerate wound healing in rats through regulating oxidative-inflammatory markers and stimulating collagen production Pharmacological Research - Modern Chinese Medicine · 2026
    3. Locally Delivered Umbilical Cord Mesenchymal Stromal Cells Reduce Chronic Inflammation in Long-Term Nonhealing Wounds: A Randomized Study Stem Cells International · 2020 · 14 citations
    4. Depression and anxiety, peripheral blood inflammatory factors, and stress levels on therapeutic outcomes in patients with chronic wounds World Journal of Psychiatry · 2024 · 2 citations
    5. Editorial: Inflammation, stem cells and wound healing in skin aging Frontiers in Cell and Developmental Biology · 2022
    6. Cellular and molecular mechanisms of repair in acute and chronic wound healing British Journal of Dermatology · 2015 · 908 citations
    7. A stretchable wireless wearable bioelectronic system for multiplexed monitoring and combination treatment of infected chronic wounds Science Advances · 2023 · 319 citations
    8. Orchestration of Mesenchymal Stem/Stromal Cells and Inflammation During Wound Healing Stem Cells Translational Medicine · 2023
    9. miR-19a/b and miR-20a Promote Wound Healing by Regulating the Inflammatory Response of Keratinocytes Journal of Investigative Dermatology · 2020 · 90 citations
    10. Application and progress of induced pluripotent stem in chronic wound healing: a narrative review BMC Plastic and Reconstructive Surgery · 2026
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