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    Did you mean Chronic Inflammation?
    Glossary Chronic Inflammation

    long-term immune response causing tissue damage and disease

    Chronic inflammation, also known as persistent inflammation, is a prolonged and often harmful immune response that can last for months or even years. Unlike acute inflammation, which is a short-term response to injury or infection, chronic inflammation can result from ongoing exposure to irritants, autoimmune disorders, or unresolved acute inflammation. This persistent state can lead to tissue damage and is associated with various diseases, including arthritis, cardiovascular disease, and certain types of alopecia.

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    1. Macrophage Related Chronic Inflammation in Non-Healing Wounds Frontiers in Immunology · 2021 · 228 citations
    2. Long Ya Cao (Agrimonia pilosa Ledeb.) extract and its bioactive constituent (agrimonolide) attenuate chronic inflammation and accelerate wound healing in rats through regulating oxidative-inflammatory markers and stimulating collagen production Pharmacological Research - Modern Chinese Medicine · 2026
    3. Locally Delivered Umbilical Cord Mesenchymal Stromal Cells Reduce Chronic Inflammation in Long-Term Nonhealing Wounds: A Randomized Study Stem Cells International · 2020 · 14 citations
    4. Depression and anxiety, peripheral blood inflammatory factors, and stress levels on therapeutic outcomes in patients with chronic wounds World Journal of Psychiatry · 2024 · 2 citations
    5. Editorial: Inflammation, stem cells and wound healing in skin aging Frontiers in Cell and Developmental Biology · 2022
    6. Cellular and molecular mechanisms of repair in acute and chronic wound healing British Journal of Dermatology · 2015 · 908 citations
    7. A stretchable wireless wearable bioelectronic system for multiplexed monitoring and combination treatment of infected chronic wounds Science Advances · 2023 · 319 citations
    8. Orchestration of Mesenchymal Stem/Stromal Cells and Inflammation During Wound Healing Stem Cells Translational Medicine · 2023
    9. miR-19a/b and miR-20a Promote Wound Healing by Regulating the Inflammatory Response of Keratinocytes Journal of Investigative Dermatology · 2020 · 90 citations
    10. Application and progress of induced pluripotent stem in chronic wound healing: a narrative review BMC Plastic and Reconstructive Surgery · 2026
    11. Small extracellular vesicles from mesenchymal stem cells: A potential Weapon for chronic non-healing wound treatment Frontiers in Bioengineering and Biotechnology · 2023 · 19 citations
    12. Synergistic Wound Healing: Unraveling the Multi-Target Effects of Traditional Chinese Medicine and Its Biomaterials on Chronic Wound Pathways International Journal of Nanomedicine · 2025 · 5 citations
    13. Innovative Functional Biomaterials as Therapeutic Wound Dressings for Chronic Diabetic Foot Ulcers International Journal of Molecular Sciences · 2023 · 12 citations
    14. The Immune Functions of Keratinocytes in Skin Wound Healing International Journal of Molecular Sciences · 2020 · 147 citations
    15. Targeting Oxidative Stress and Mitochondrial Dysfunction in the Treatment of Impaired Wound Healing: A Systematic Review Antioxidants · 2018 · 280 citations
    16. Toward understanding scarless skin wound healing and pathological scarring F1000Research · 2019 · 113 citations
    17. Immunomodulatory roles of regulatory T cells in cutaneous wound healing: mechanisms and therapeutic opportunities Frontiers in Immunology · 2026
    18. eLife assessment: Decoding the complexity of delayed wound healing following Enterococcus faecalis infection 2024
    19. Wound healing: cellular mechanisms and pathological outcomes Open Biology · 2020 · 1425 citations
    20. Wound Healing and the Use of Medicinal Plants Evidence-based Complementary and Alternative Medicine · 2019 · 170 citations
    21. Ginseng-derived nanoparticles induce skin cell proliferation and promote wound healing Journal of Ginseng Research · 2022 · 112 citations
    22. Wound Microbiota and Its Impact on Wound Healing International journal of molecular sciences · 2023 · 2 citations
    23. Mechanistic Insights into Plant-Derived Exosomes, Their Cross-Kingdom Effects, and Potential Biomedical Applications in Skin Wounds Repair Plants · 2026
    24. Research advances on postbiotics in promoting skin wound healing: mechanisms, formulations, and clinical translation Frontiers in Immunology · 2026
    25. Obesity and Wound Healing: Focus on Mesenchymal Stem Cells Life · 2023 · 3 citations
    26. Fibroblasts: Immunomodulatory factors in refractory diabetic wound healing Frontiers in Immunology · 2022 · 20 citations
    27. Engineering Immunomodulatory Biomaterials to Drive Skin Wounds toward Regenerative Healing Cold Spring Harbor Perspectives in Biology · 2022 · 18 citations
    28. Modulation of macrophage functions by ECM-inspired wound dressings – a promising therapeutic approach for chronic wounds Biological Chemistry · 2021 · 9 citations
    29. Multi-functional nanozyme-integrated astragalus polysaccharide hydrogel for targeted phased therapy in diabetic wound healing Nano Today · 2025 · 14 citations
    30. Engineering MMP9-Responsive Antioxidative Micelle-Hydrogel Dressings for Sequential Inflammatory Remodeling and Pro-Angiogenesis in Diabetic Wound Healing Precision medicine and engineering. · 2026