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research Loss of epidermal Evi/Wls results in a phenotype resembling psoriasiform dermatitis

51 citations , August 2013 in “The Journal of experimental medicine/The journal of experimental medicine”

This study found that Wnt secretion is important for maintaining skin homeostasis in mice, as Evi-deficient mice developed psoriasis-like skin lesions and had an imbalance in immune cell populations.

research Animal Models of Psoriasis – What Can We Learn from Them?

127 citations , April 1999 in “Journal of Investigative Dermatology”

This review compares various rodent models that reflect aspects of psoriasis with human psoriasis and potential applications for research, reporting no new clinical findings.

research Effects of Visible Light on the Skin^†

195 citations , January 2008 in “Photochemistry and Photobiology”

This review discusses the effects of visible light on human skin, highlighting its role in pigmentation, thermal damage, and the treatment of several skin conditions, while noting limited sunscreen protection against it; no new clinical results are reported.

research MicroRNAs in the skin: role in development, homoeostasis and regeneration

31 citations , July 2017 in “Clinical Science”

This review discusses the role of microRNAs in skin function and potential therapeutic applications, emphasizing their importance in wound healing and disease management, though it reports no new experimental findings.

research Sonic Hedgehog signalling in the regulation of barrier tissue homeostasis and inflammation

23 citations , October 2021 in “FEBS Journal”

This review examines the role of Sonic Hedgehog signaling in the maintenance and repair of skin and lung barriers, and its influence on inflammation and atopic diseases; it presents no new clinical findings.

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Community Join

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community DHT Itch and Oily Scalp Explained (and how to fix it)

90 upvotes 3 months ago

Malassezia overgrowth can worsen oily scalp and inflammation, contributing to hair loss. Treatments include antifungal shampoos, C6/C8 MCT oil, low-dose isotretinoin, finasteride, and dutasteride.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 2 years ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Fresh off the press: Dutasteride may cause chronic infertility

in Research/Science 643 upvotes 1 year ago

Dutasteride may cause chronic infertility by reducing semen volume and motility, with concerns about irreversible prostate fibrosis. Users consider switching to finasteride or using treatments like minoxidil and microneedling, weighing hair preservation against fertility.

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Learn

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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Hair Loss Treatments
Chronic Care of RichmondRichmond, VA · US

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