15 citations
,
May 2010 in “International Journal of Cosmetic Science”
This review discusses new developments in understanding the structure and properties of keratin fiber cellmembranecomplexes, without reporting new experimental results.
This study suggests that the cellmembranecomplex in hair cuticles contains hydrophilic regions with disulfide bonds allowing polymer uptake and hydrophobic lamella-like lipid layers.
4 citations
,
January 2006 in “International Journal of Cosmetic Science”
This study found that scanning electron microscopy with argon sputter etching visualizes hair lipids at the cellmembranecomplex as distinctive convex structures, shedding light on their role and localization in human hair.
This study found that washing hair with surfactants reduces the internal density of hair due to cuticle lifting, and suggests that a cuticle-sealing strategy can inhibit this effect and maintain hair homeostasis.
MCL-1 is important for hair follicle stem cell survival, but its impact on human hair regrowth is unclear. Minoxidil and finasteride are the main treatments, with doubts about new discoveries leading to effective human solutions soon.
Minoxidil works by opening potassium channels, leading to reduced blood pressure and potential side effects like reflex tachycardia. It is used for hair growth and affects blood pressure at high doses.
Pelage PP405 is a new hair loss treatment in trials, potentially reactivating dormant hair follicles without affecting hormones. Results are expected in February 2025, offering an alternative to minoxidil and finasteride.
Dutasteride takes 1-3 months to affect scalp DHT levels, not just a week. The prostate absorbs Dutasteride faster than the scalp due to different vascular networks and enzyme densities.
A 27-year-old male physician improved hair density using minoxidil 5% foam and finasteride 1mg every other day, with initial sexual side effects that subsided. He recommends trying finasteride for a year but warns against dutasteride due to potential liver effects.